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CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
A gene CREPT is reported that is preferentially expressed in diverse human tumors and a mechanism where CREPT increases cyclin D1 transcription during tumorigenesis is revealed, through enhancing the recruitment of RNAPII to the promoter region, possibly as well as chromatin looping. Expand
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer
PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. Expand
Varp interacts with Rab38 and functions as its potential effector.
This study demonstrates that Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo, and proposes Varp serves as both an effector and a GEF by interacting with different Rabs in mammalian cells. Expand
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
It is reported that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mechanism, and suggests that negative regulation of the Runx 2 protein by CHIP is critical in the commitment of precursor cells to differentiate into the osteoblast lineage. Expand
IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling
It is shown that the orphan receptor IL-17RD (Sef, similar expression to FGF genes orIL-17RLM) is associated and colocalized with IL- 17R, therefore providing novel evidence for IL-16 signaling through a heteromeric and/or homomeric receptor complex. Expand
GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway
It is suggested that GABARAPL1 as a tumor repressor inhibits Wnt signaling via mediating Dvl2 degradation through the autophagy pathway. Expand
GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.
GdX (UBL4A) promotes STAT3 dephosphorylation via mediating the interaction between TC45 (the nuclear isoform of TC-PTP) and STAT3 specifically and stabilizes the TC45-STAT3 complex to bestow upon STAT3 an efficient deph phosphorylation by TC45. Expand
Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation*
TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-κB signaling, which may explain the role of TNFR2 in inflammatory diseases including nephritis. Expand
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.
It is found that chondrocyte-specific deletion of BMP type I receptor a (Bmpr1a) rescued the bone overgrowth phenotype observed in Fgfr3 deficient mice by reducing chondROcyte differentiation. Expand
p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand