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Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy.
A great deal of new information has arisen in the recent years concerning inhibin physiology and clinical relevance in reproductive medicine. It is now recognized that the two inhibin isoforms, namedExpand
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Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.
BACKGROUND Growth factors are proteins secreted by a number of cell types that are capable of modulating cellular growth, proliferation and cellular differentiation. It is well accepted that uterineExpand
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Angiotensin (1–7) and its receptor Mas are expressed in the human testis: implications for male infertility
The presence of classical components of the renin-angiotensin system has been demonstrated in the male reproductive tract, mainly in the testes and epididymis. The objective of this study was toExpand
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Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery, and in hypertensive patients.
Allopregnanolone is a neuroactive steroid measurable in peripheral circulation. The aim of the present study was to investigate the presence and the possible changes in serum allopregnanolone andExpand
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Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessiveExpand
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The Vasoactive Peptide Angiotensin-(1—7), Its Receptor Mas and the Angiotensin-converting Enzyme Type 2 are Expressed in the Human Endometrium
Angiotensin (Ang)-(1-7) is one of the major active components of the renin-angiotensin system, produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2), which acts through aExpand
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Activin A Stimulates Interleukin 8 and Vascular Endothelial Growth Factor Release From Cultured Human Endometrial Stromal Cells: Possible Implications for the Pathogenesis of Endometriosis
Background: Activin A is an endometrial secretory product involved in inflammation and angiogenesis. The present study aimed to evaluate the effect of activin A and its antagonist follistatin onExpand
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Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis.
BACKGROUND The recruitment of immune cells by chemokines and the regulation of endometrial cell apoptosis are critical aspects of endometriosis biology. Here, we review the local (paracrine) andExpand
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Increased maternal serum activin A but not follistatin levels in pregnant women with hypertensive disorders.
Activin A levels are elevated in maternal serum of pregnant women with hypertensive disturbances. Because follistatin is a circulating binding protein for activin A, the present study was designed toExpand
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Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.
The vasodilator/antiproliferative peptide angiotensin-(1-7) [ANG-(1-7)] is released into the corpus cavernosum sinuses, but its role in erectile function has yet to be defined. In this study, weExpand
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