• Publications
  • Influence
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
TLDR
Mechanistic studies using Dmp1-null mice demonstrated that absence of DMP1 results in defective osteocyte maturation and increased FGF23 expression, leading to pathological changes in bone mineralization, suggesting a bone-renal axis that is central to guiding proper mineral metabolism. Expand
International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions.
TLDR
This is a review of the methodology of the PDCs and selected ISCD Official Positions. Expand
Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference.
TLDR
The methodology and results of the 2007 Pediatric PDC are described, and a summary of all ISCD Official Positions is described, including the ones recently adopted by this 2007 Pediatrics PDC and the 2007 Lansdowne, Virginia, USA Adult PDC. Expand
Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions.
TLDR
Experts in the field of WBV invited to provide suggestions on how the intervention should be described in such reports on how to improve the quality of reports about WBV treatment studies. Expand
CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta
TLDR
In humans, CRTAP mutations are associated with the clinical spectrum of recessive osteogenesis imperfecta, including the type II and VII forms, and dysregulation of prolyl 3-hydroxylation is a mechanism for connective tissue disease. Expand
Osteogenesis imperfecta
TLDR
The classification of OI into four types was based on clinical findings, but more recently additional types OI (types V-XI) have been ascertained, based on the identification of different mutations. Expand
Bone growth in length and width: the Yin and Yang of bone stability.
  • F. Rauch
  • Biology, Medicine
  • Journal of musculoskeletal & neuronal…
  • 1 July 2005
TLDR
Future research will have to address the question how periosteal bone cells manage to integrate mechanical, hormonal and other input to shape bones that are as strong as they need to be. Expand
The 'muscle-bone unit' during the pubertal growth spurt.
TLDR
Results are compatible with the view that bone development is driven by muscle development, although the data do not exclude the hypothesis that the two processes are independently determined by genetic mechanisms. Expand
Type V Osteogenesis Imperfecta: A New Form of Brittle Bone Disease
TLDR
OI type V is a new form of autosomal dominant OI, which does not appear to be associated with collagen type I mutations, and the genetic defect underlying this disease remains to be elucidated. Expand
Static and dynamic bone histomorphometry in children with osteogenesis imperfecta.
TLDR
Evidence of defects in all three mechanisms, which normally lead to an increase in bone mass during childhood, are regarded as a disease in which a single genetic defect in the osteoblast interferes with multiple mechanisms that normally ensure adaptation of the skeleton to the increasing mechanical needs during growth. Expand
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