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Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β*
- S. Hehner, M. Heinrich, +6 authors M. Schmitz
- The Journal of Biological Chemistry
- 16 January 1998
Inhibition of NF-κB by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-α and the analysis of the cellular redox state by fluorescence-activated cell sorter showed that the SLs had no direct or indirect anti-oxidant properties. Expand
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
Inhibition of NF-kappa B by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-alpha and analysis of the cellular redox state by fluorescence-activated cell sorter showed that the SLs had no direct or indirect anti-oxidant properties. Expand
Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart
Results indicate that insulin-induced memory improvement can be enhanced by using rapid-acting insulin analog insulin aspart (ASP-I), and may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease. Expand
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
- S. Bergmann, V. Shatrov, F. Ratter, S. Schiemann, K. Schulze-Osthoff, V. Lehmann
- Chemistry, Medicine
- Journal of immunology
- 15 August 1994
This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha-mediated cytotoxicity, but does not modulate activation of NF-kappa B transcription factor controlling the… Expand
Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release.
- A. Ushmorov, F. Ratter, V. Lehmann, W. Dröge, V. Schirrmacher, V. Umansky
- Biology, Medicine
- 1 April 1999
We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also… Expand
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function
- T. Forst, G. Michelson, +5 authors A. Pfützner
- Diabetic medicine : a journal of the British…
- 1 September 2012
Diabet. Med. 29, 1115–1118 (2012)
Nitric oxide-mediated apoptosis in human breast cancer cells requires changes in mitochondrial functions and is independent of CD95 (APO-1/Fas).
It is suggested that the mechanism of NO-mediated activation of the caspase cascade and subsequent apoptosis in human breast cancer cells required mitochondrial damage but not theactivation of the CD95/CD95L pathway. Expand
Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.
It is concluded that Ado and Homo together enhance the effectiveness of TNF-alpha in vitro and in vivo, results that may have therapeutic implications. Expand
Tumor necrosis factor-alpha-induced cell killing and activation of transcription factor NF-kappaB are uncoupled in L929 cells.
- S. Hehner, T. Hofmann, F. Ratter, A. Dumont, W. Dröge, M. Schmitz
- The Journal of biological chemistry
The reduction of NF-kappaB-mediated gene expression by the synthetic steroid dexamethasone was associated with a decrease in TNF-alpha-mediated cell killing, suggesting that NF- kappaB does not protect L929 cells from TNF -alpha-induced cell death. Expand
HIV type 1 glycoprotein 120 amplifies tumor necrosis factor-induced NF-kappa B activation in Jurkat cells.
- V. Shatrov, F. Ratter, A. Gruber, W. Dröge, V. Lehmann
- Biology, Medicine
- AIDS research and human retroviruses
- 1 September 1996
The data suggest that gp120 potentiates TNF-induced NF-kappa B activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2. Expand