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Design, synthesis and anticancer evaluation of novel tetrahydroquinoline derivatives containing sulfonamide moiety.
TLDR
The present work reports the synthesis of some novel quinoline and pyrimido[4,5-b]quinoline derivatives bearing a substituted or unsubstituted sulfonamide moiety, which showed interesting cytotoxic activities compared to a reference drug. Expand
In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety.
TLDR
The present work reports the synthesis of twenty novel quinoline and pyrimido[4,5-b]quinoline derivatives bearing a sulfonamide moiety designed in compliance with the general pharmacophoric requirements for CA inhibiting anticancer drugs, as this may play a role in their anticancer activity. Expand
Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents.
TLDR
The radiosensitizing ability of some of the synthesized compounds was studied and the results showed an increase in the cell killing effect of γ-radiation after combination with the tested compounds. Expand
Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.
TLDR
Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines revealed their marked potency when compared with known anticancer drugs. Expand
Synthesis of some novel quinolines and pyrimido [4,5-b] quinolines bearing A sulfonamide moiety as potential anticancer and radioprotective agents.
TLDR
Compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug and exhibited in vivo radioprotective activity against gamma-irradiation in mice. Expand
Synthesis of some new pyrazolo[3,4-d]pyrimidine derivatives of expected anticancer and radioprotective activity.
TLDR
A new series of pyrazolo[3,4-d]pyrimidines derivatives were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line, and compound 5 showed significant radioprotective effect. Expand
Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents.
TLDR
The results showed a profound anti-tumor effect of 25e that accompanies a significant increase and decrease in the levels of GSK-3β and cyclin D1, respectively. Expand
Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents.
TLDR
Some novel 1,3,4-trisubstituted pyrazoles showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone and COX-1/COX-2 isozyme selectivity showed equal inhibition to both isoforms. Expand
Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.
TLDR
The most potent aromatase inhibitors 11 and 13 showed the lowest IC50 on the target enzyme and showed a marked increase in Bax level up to 55,000 folds, and down-regulation in Bcl2 to 5.24*10-4 folds, in comparison to the control. Expand
Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives
TLDR
All the newly synthesized compounds were evaluated for their in vitro anticancer activity against a human liver cell line (HEPG2) and showed higher activity than the reference drug doxorubicin. Expand
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