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Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins.
TLDR
The objective of the present review is to provide insights into the brown spider venoms and loxoscelism based on recent results, including the biology of brown spiders, the clinical features of loxocelism and the diagnosis and therapy of brown spider bites. Expand
Improving Predictions of Protein-Protein Interfaces by Combining Amino Acid-Specific Classifiers Based on Structural and Physicochemical Descriptors with Their Weighted Neighbor Averages
TLDR
The results presented here show that the selected set of descriptors can be utilized to predict IFRs, even when homologue proteins are missing (particularly important for orphan proteins where no homologue is available for comparative analysis/indication) or, when certain conformational changes accompany interface formation. Expand
Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells.
TLDR
It was possible to suggest that berberine has promising potential as a photosensitizing agent in a photodynamic therapy, because it induced significant anticancer effects on renal carcinoma cells. Expand
Identification of Folding Intermediates of Streblin, The Most Stable Serine Protease: Biophysical Analysis
TLDR
Spectroscopic studies reveal that streblin belongs to the α+β class of proteins and exhibits stability towards chemical denaturants, guanidine hydrochloride (GuHCl), and the protein is found to exhibit strong and predominant ANS binding. Expand
Expression, purification and characterization of cold shock protein A of Corynebacterium pseudotuberculosis.
TLDR
The thermal unfolding/refolding process characterized by circular dichroism, differential scanning calorimetry and NMR spectroscopy techniques indicated that the refolding process was almost completely reversible. Expand
Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase‐D
TLDR
Results indicate the mode of action of three different LiRecDT1 inhibitors, which were able to prevent the venom toxic effects, which strengthen the idea of the importance of designing a specific drug to treat the serious clinical symptoms caused by the brown spider bite. Expand
Zika virus NS2B/NS3 proteinase: A new target for an old drug ‐ Suramin a lead compound for NS2B/NS3 proteinase inhibition‐
TLDR
The polyanion suramin is identified as a potential inhibitor of Zika virus complex NS2B/NS3 proteinase with IC50 of 47 &mgr;M and computational analysis showed that suramin block the Ser135 residue and interact with the catalytically histidine residue. Expand
Thermodynamic analysis of interactions of the Hsp90 with adenosine nucleotides: A comparative perspective.
TLDR
Evaluated interaction of either ADP or ATP with recombinant Hsp90s from different organisms by isothermal titration calorimetry suggests that selective inhibition may be more easily achieved using analogues of the HSp90-ADP bound state than those of Hsp 90-ATP boundState. Expand
Biochemical and biophysical characterization of a mycoredoxin protein glutaredoxin A1 from Corynebacterium pseudotuberculosis.
TLDR
The aim of this study was the investigation of the Glutaredoxin A1 from C. pseudotuberculosis behavior under different redox environments and the identification of lead molecules, which can be used for specific inhibitor development for this protein family. Expand
Metabolic Effects of Cobalt Ferrite Nanoparticles on Cervical Carcinoma Cells and Nontumorigenic Keratinocytes.
TLDR
Results clearly indicated that treatment with cobalt ferrite nanoparticles might cause a perturbation in cellular metabolism, and nanoparticle-treated HeLa cells demonstrated decreased concentrations of metabolites associated with cell proliferation and tumor growth. Expand
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