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Agaricus bisporus and Agaricus brasiliensis (1→6)-β-D-glucans show immunostimulatory activity on human THP-1 derived macrophages.
It is concluded that the (1→6)-β-D-glucans present an immunostimulatory activity when administered to THP-1 derived macrophages and stimulated the expression of pro- inflammatory genes as much as the pro-inflammatory control (LPS). Expand
Exopolysaccharide produced by Pleurotus sajor-caju: its chemical structure and anti-inflammatory activity.
The mannogalactan was able to reduce the nociception, in vivo, in the writhing and formalin tests and also reduced the carrageenan-induced paw edema, which indicates that it could be an effective antinociceptive and anti-inflammatory agent. Expand
D-glucans from edible mushrooms: a review on the extraction, purification and chemical characterization approaches.
The present manuscript reviews the processes of extraction, purification and chemical characterization of D-glucans, such as NMR studies, methylation analysis, Smith degradation, and some other methodologies employed in carbohydrate chemistry characterization. Expand
Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius.
Data showed that the glucan had potent anti-inflammatory and analgesic (antinociceptive) activities, possibly by the inhibition of pro-inflammatory cytokines. Expand
Structural characterization of a polysaccharide and a beta-glucan isolated from the edible mushroom Flammulina velutipes.
Two polysaccharides were isolated from the basidiomycete Flammulina velutipes, via successive hot extraction with water, 2% and 25% aq. KOH, and then submitted to freeze-drying. The precipitateExpand
A 3-O-methylated mannogalactan from Pleurotus pulmonarius: structure and antinociceptive effect.
A mannogalactan was tested for its effects on the acetic acid-induced writhing reaction in mice, a typical model for inflammatory pain, causing a marked and dose-dependent inhibition of the nociceptive response, and an inflammatory response was not inhibited. Expand
Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition.
It is demonstrated that β-D-Glucan could constitute an attractive molecule of interest for the development of new analgesic drugs. Expand
Structural characterization and anti-inflammatory activity of a linear β-D-glucan isolated from Pleurotus sajor-caju.
The results demonstrate that this β-d-glucan from P. sajor-caju exhibits a significant anti-inflammatory activity and reduced the number of total leukocytes and myeloperoxidase levels induced by LPS. Expand
Structure of two glucans and a galactofuranomannan from the lichen Umbilicaria mammulata
The three main polysaccharides from the lichenized fungus Umbilicaria mammulata were isolated and characterized. Their structures were determined using GC-MS of derived alditol acetates,Expand
Mushroom heteropolysaccharides: A review on their sources, structure and biological effects.
This review intends to organize and classify the information described up to now about polysaccharides obtained from different sources of mushroom-forming fungi, Basidiomycetes, Ascomycete and Hybrid mushrooms, and provides a brief reflection on how the chemical studies have been carried out. Expand