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A Quantitative Promoter Methylation Profile of Prostate Cancer
TLDR
The data demonstrate the existence of a progressive increase of promoter methylation levels of several cancer-related genes in prostate carcinogenesis, providing additional markers to augment molecular detection of prostate carcinoma.
High Promoter Methylation Levels of APC Predict Poor Prognosis in Sextant Biopsies from Prostate Cancer Patients
TLDR
High-level APC promoter methylation is an independent predictor of poor prognosis in prostate biopsy samples and might provide relevant prognostic information for patient management.
Quantitative RARbeta2 hypermethylation: a promising prostate cancer marker.
TLDR
This quantitative assay represents a novel and promising molecular marker that may augment current approaches for prostate cancer detection and is able to discriminate between neoplastic and non-neoplastic tissue, with 94.9% sensitivity and 100% specificity.
The order of genetic events associated with colorectal cancer progression inferred from meta‐analysis of copy number changes
TLDR
A novel genetic pathway for CRC progression is presented that distinguishes the Dukes' stages and identifies early and late events in both primary carcinomas and liver metastases and supplements these findings with a list of potential target genes for the specific alterations from a publicly available microarray expression dataset of CRC.
Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis
TLDR
Comparison of genomic hybridisation analysis of 26 tumours from 12 breast cancer patients with multiple ipsilateral and/or bilateral carcinoma lesions concludes that CGH analysis of multiple breast carcinomas followed by unsupervised hierarchical clustering of the genomic imbalances is more reliable than previous criteria to determine the tumours’ clonal relationship in individual patients.
TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.
TLDR
It is demonstrated for the first time that the TMPRSS2-ERG fusion gene can be detected in a proportion of HGPIN lesions and that this molecular rearrangement is an early event that may precede chromosome-level alterations in prostate carcinogenesis.
Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases
TLDR
It is concluded that primary breast carcinomas may be composed of several genetically heterogeneous and spatially separated cell populations and that paired primary breast tumors and lymph node metastases often present divergent clonal evolution, indicating that metastases may occur relatively early during breast carcinogenesis.
Epigenetic Heterogeneity of High-Grade Prostatic Intraepithelial Neoplasia: Clues for Clonal Progression in Prostate Carcinogenesis
TLDR
It is concluded that APC and RARβ2 hypermethylation is frequent in normal prostate tissue and the progressive enrichment in cells carrying methylated alleles observed in high-grade PIN and prostate carcinoma is consistent with clonal progression.
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
TLDR
It is reported that FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer and that intratumor genetic heterogeneity of ETS rearrangements can occasionally be found in index primary tumors.
Cysteine-Rich Secretory Protein-3 (CRISP3) Is Strongly Up-Regulated in Prostate Carcinomas with the TMPRSS2-ERG Fusion Gene
TLDR
It is shown that CRISP3 is a direct target of ERG that is strongly overexpressed in PCa with the TMPRSS2-ERG fusion gene and is associated with significant expression alterations in genes involved in critical cellular pathways that define a subset of locally advanced PCa.
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