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Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex
The purinergic receptor P2X7 is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X7 receptors inExpand
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Pannexin1 Channels Contain a Glycosylation Site That Targets the Hexamer to the Plasma Membrane*
Pannexins are newly discovered channel proteins expressed in many different tissues and abundantly in the vertebrate central nervous system. Based on membrane topology, folding and secondaryExpand
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The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes*
The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In primaryExpand
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Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”
Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels are among the mechanisms proposed byExpand
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Ptf1a determines horizontal and amacrine cell fates during mouse retinal development
The vertebrate neural retina comprises six classes of neurons and one class of glial cells, all derived from a population of multipotent progenitors. There is little information on the molecularExpand
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Barhl1 Regulates Migration and Survival of Cerebellar Granule Cells by Controlling Expression of the Neurotrophin-3 Gene
The neurons generated at the germinal rhombic lip undergo long distance migration along divergent pathways to settle in widely dispersed locations within the hindbrain, giving rise to cerebellarExpand
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Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition.
Recent studies reveal that long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and lncRNA MALAT-1 expression is upregulated in some tumors. However,Expand
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Pannexin 1 contributes to ATP release in airway epithelia.
ATP is a paracrine regulator of critical airway epithelial cell functions, but the mechanism of its release is poorly understood. Pannexin (Panx) proteins, related to invertebrate innexins, formExpand
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A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.
  • F. Qiu, G. Dahl
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 1 February 2009
Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel. Pannexin 1 channel activityExpand
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Structure of a Hydroxyproline (Hyp)-Arabinogalactan Polysaccharide from Repetitive Ala-Hyp Expressed in Transgenic Nicotiana tabacum*
A synthetic gene encoding the fusion protein (Ala-Hyp)51-enhanced green fluorescent protein expressed in Nicotiana tabacum cells produced a fusion glycoprotein with all proline residues hydroxylatedExpand
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