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- Publications
- Influence
Protective role for club cell secretory protein-16 (CC16) in the development of COPD
- Maria E. Laucho-Contreras, F. Polverino, +11 authors C. Owen
- Medicine
- European Respiratory Journal
- 19 February 2015
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We measured CC16… Expand
B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.
- F. Polverino, B. Cosio, +13 authors C. Owen
- Medicine
- American journal of respiratory and critical care…
- 15 September 2015
RATIONALE
Patients with chronic obstructive pulmonary disease (COPD) have increased pulmonary lymphoid follicle (LF) counts. B cell-activating factor of tumor necrosis factor family (BAFF) regulates… Expand
Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice
- S. Cloonan, Kimberly Glass, +26 authors A. Choi
- Medicine
- Nature Medicine
- 9 December 2015
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element–binding protein 2 (IRP2) as an… Expand
Anatomy and neuro-pathophysiology of the cough reflex arc
- M. Polverino, F. Polverino, M. Fasolino, F. Andò, A. Alfieri, F. de Blasio
- Medicine
- Multidisciplinary Respiratory Medicine
- 18 June 2012
Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner… Expand
A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease
- F. Polverino, Maria E. Laucho-Contreras, +9 authors C. Owen
- Medicine
- American journal of respiratory and critical care…
- 1 June 2017
Rationale: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. Objectives: To determine… Expand
ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils: Regulation of Expression and Contributions to Extracellular Matrix Protein Degradation during Acute Lung Injury
- Robin Roychaudhuri, Anja H Hergrueter, +4 authors C. Owen
- Biology, Medicine
- The Journal of Immunology
- 1 September 2014
A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes and macrophages. In this study, we report that ADAM9 is also a product of human and murine… Expand
Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)
- Maria E. Laucho-Contreras, F. Polverino, Y. Tesfaigzi, A. Pilon, B. Celli, C. Owen
- Medicine
- Expert opinion on therapeutic targets
- 11 February 2016
ABSTRACT Introduction: Club cell protein 16 (CC16) is the most abundant protein in bronchoalveolar lavage fluid. CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive… Expand
Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine…
- Alfonso Schiavo, M. Renis, M. Polverino, A. Iannuzzi, F. Polverino
- Medicine
- Multidisciplinary Respiratory Medicine
- 25 May 2016
BackgroundHypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients… Expand
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.
- Zhiqiang Jiang, Taotao Lao, +17 authors Xiaobo Zhou
- Medicine
- American journal of respiratory and critical care…
- 15 July 2016
RATIONALE
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, the mechanisms by… Expand
B cells in chronic obstructive pulmonary disease: moving to center stage.
- F. Polverino, L. Seys, K. Bracke, C. Owen
- Medicine
- American journal of physiology. Lung cellular and…
- 1 October 2016
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). Although research studies focused initially on the… Expand