• Publications
  • Influence
Sequential phases of cortical specification involve Neurogenin‐dependent and ‐independent pathways
Neocortical projection neurons, which segregate into six cortical layers according to their birthdate, have diverse morphologies, axonal projections and molecular profiles, yet they share a commonExpand
  • 357
  • 52
  • PDF
Establishment of axon-dendrite polarity in developing neurons.
Neurons are among the most highly polarized cell types in the body, and the polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain.Expand
  • 439
  • 43
LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons
The polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. We show here that the serine/threonine kinase LKB1, previously implicatedExpand
  • 379
  • 42
Semaphorin 3A is a chemoattractant for cortical apical dendrites
The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pialExpand
  • 675
  • 35
  • PDF
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
How to shape mitochondrial networks Mitochondria undergo fragmentation or fusion in response to changes in cellular metabolism. Toyama et al. report that adenosine monophosphate-activated proteinExpand
  • 450
  • 28
  • PDF
KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner
The molecular mechanisms controlling the termination of cortical interneuron migration are unknown. Here, we demonstrate that, prior to synaptogenesis, migrating interneurons change theirExpand
  • 290
  • 27
The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis
During brain development, proper neuronal migration and morphogenesis is critical for the establishment of functional neural circuits. Here we report that srGAP2 negatively regulates neuronalExpand
  • 273
  • 26
Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation
Structural genomic variations represent a major driving force of evolution, and a burst of large segmental gene duplications occurred in the human lineage during its separation from nonhumanExpand
  • 274
  • 23
Phosphorylation of Neurogenin2 Specifies the Migration Properties and the Dendritic Morphology of Pyramidal Neurons in the Neocortex
The molecular mechanisms specifying the dendritic morphology of different neuronal subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor Neurogenin2 (Ngn2) is bothExpand
  • 339
  • 22
  • PDF
TGF-β Signaling Specifies Axons during Brain Development
In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axonExpand
  • 187
  • 19