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Cyclophosphamide and urinary bladder toxicity.
Summary Single doses of cyclophosphamide can regularly induce bladder damage in rats and dogs. Changes develop rapidly and, within 24 hours, consist of ulceration of the mucosal epithelium,… Expand
Inhibition of leukemias in man by L-asparaginase.
The renal clearance of thiosulfate with observations on its volume distribution.
The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides.
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
2'-Fluoro-5-methyl-l-beta-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography. FMAU is a… Expand
The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
Summary Lethal doses of methotrexate in mice cause a prolonged inhibition of proliferation in the epithelium of small intestine. As early as 6 hr after such doses, a few karyorrhectic cells are… Expand
Cytotoxic effects of 1-beta-D-arabinofuranosyl-5-fluorocytosine and of 1-beta-D-arabinofuranosylcytosine in proliferating tissues in mice.
Hydroxyurea. I. Acute cell death in proliferating tissues in rats.
- F. Philips, S. Sternberg, H. Schwartz, A. Cronin, J. E. Sodergren, P. Vidal
- Chemistry, Medicine
- Cancer research
Summary Hydroxyurea induces karyorrhexis in intestinal crypts, bone marrow, and germinal centers of all lymphoid tissues within a few hr after injection. Acute, selective cytotoxic effects are… Expand
Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin.
The two anthracycline antitumor antibiotics, adriamycin and daunomycin, have been tested for tumorigenic activity, and the results confirm previous findings that they can induce mammary tumors in… Expand
6-Aminonicotinamide and acute degenerative changes in the central nervous system.