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Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.

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Inflammation and Pregnancy

During pregnancy, the balance of Th1 (cell-mediated immunity) and Th2 (humoral immunity) cytokines is characterized by an initial prevalence of Th2 cytokines, followed by a progressive shift toward Th1 predominance late in gestation, that when is abnormal, may initiate and intensify the cascade of inflammatory cytokine production involved in adverse pregnancy outcomes.
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Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences.

It is demonstrated that although men show an age-related decrease, serum allopregnanolone levels in women do not change with age and correlate with P levels during the menstrual cycle and in response to endocrine tests.
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Genetic, hormonal and metabolic aspects of PCOS: an update

Polycystic ovary syndrome is a complex endocrine disorder affecting 5–10 % of women of reproductive age and patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
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Insulin-lowering agents in the management of polycystic ovary syndrome.

In a high percentage of patients, treatment with metformin is followed by regularization of menstrual cycle, reduction in hyperandrogenism and in cardiovascular risk factors, and improvement in response to therapies for induction of ovulation.
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Consensus on women's health aspects of polycystic ovary syndrome (PCOS).

Current knowledge is summarized and knowledge gaps regarding various women's health aspects of PCOS are identified, including adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health and finally cancer risk.
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Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy.

This review covers the most recent advances on the role of inhibins in human reproductive function and newly recognized alterations of inhibin levels in gynaecological diseases as well as in normal and pathological pregnancy are discussed, with particular emphasis on the potential clinical usefulness of assessing inhibition levels in serum and other biological fluids.
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Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management.

In women with deep endometriosis, surgery is the therapy of choice for symptomatic patients when deep lesions do not improve with a medical treatment.
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Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.

Growth factors play an important role in the mechanisms involved in myometrial patho-physiology, and are searched for in the database MEDLINE and Google Scholar for articles with content related to growth factors acting on myometrium.
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Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms.

A growing number of studies has provided strong evidence that fetal membranes (amnion, chorion) and maternal decidua are capable of hormone production and metabolism and, when containing hormonal receptors, serve as endocrine organs.
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