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Validation of new methods.
Important considerations in analytical method validation will be discussed and may be used as guidance by scientists wishing to develop and validate analytical methods. Expand
Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry
The STA procedure allowed the detection of mephedrone, butylone, methylone, and their metabolites in urine of rats treated with doses corresponding to those reported for abuse of amphetamines and should be suitable for proof of an intake of the bk-designer drugs in human urine. Expand
Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy').
The phase I and II metabolites of the designer drugs methylenedioxyamphetamine, MDA, MDMA, MDE, R,S-methylenedioxymethamphetamine (MDMA) and R, S-N-methyl-benzodioxazolylbutanamine (MBDB) were identified and GC-MS procedures were developed for the toxicological analysis in urine and plasma. Expand
The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers
The different pharmacokinetic properties of the MDMA enantiomers may be caused by enantioselective metabolism by CYP2C19 and CYD2D6. Expand
Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology.
An overview of recent developments in LC-MS(/MS)-based systematic toxicological analysis using triple quadrupole or ion trap instruments focusing on the literature published after 2006 is provided. Expand
Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity
It is indicated that MDMA and, possibly, MDA are more important determinants of brain 5-HT neurotoxicity in the rat than HHMA and HMMA and bring into question the role of metabolites (including 5-NAC-HHMA) in MDMA neurotoxicity. Expand
Practical aspects concerning validation and quality control for forensic and clinical bioanalytical quantitative methods
Reporting reliable analytical data is the backbone of forensic and clinical bioanalytical research and applications. Therefore, international agreement concerning validation and quality controlExpand
Bioanalytical method validation and its implications for forensic and clinical toxicology – A review
Abstract The reliability of analytical data is very important to forensic and clinical toxicologists for the correct interpretation of toxicological findings. This makes (bio)analytical methodExpand
Automated mass spectral deconvolution and identification system for GC-MS screening for drugs, poisons, and metabolites in urine.
AMDIS proved to be a reliable and powerful tool for daily routine and emergency toxicology but can identify only targets present in the user-defined target library and may therefore not indicate unknown compounds that might be relevant in clinical and forensic toxicology. Expand
The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxyethylamphetamine and Its Single Enantiomers
Different pharmacokinetic properties of MDEA enantiomers observed in vivo are therefore partially caused by P450-dependent enantioselective metabolism, which was particularly pronounced in the case of CYP2C19. Expand