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EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues
Translating Polyproline Translation of messenger RNA into protein is carried out by the ribosome, together with a variety of accessory factors, which offer the potential for regulation of thisExpand
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An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation.
The elongation cycle of protein synthesis is completed by translocation, a rearrangement during which two tRNAs bound to the mRNA move on the ribosome. The reaction is promoted by elongation factor GExpand
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Sequence of steps in ribosome recycling as defined by kinetic analysis.
After termination of protein synthesis in bacteria, ribosomes are recycled from posttermination complexes by the combined action of elongation factor G (EF-G), ribosome recycling factor (RRF), andExpand
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Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation.
Translocation, a coordinated movement of two tRNAs together with mRNA on the ribosome, is catalyzed by elongation factor G (EF-G). The reaction is accompanied by conformational rearrangements of theExpand
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The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome.
The signal recognition particle (SRP) from Escherichia coli, composed of Ffh protein and 4.5S RNA, mediates membrane targeting of translating ribosomes displaying a signal or signal-anchor sequence.Expand
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Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation
Summary Programmed –1 ribosomal frameshifting (−1PRF) is an mRNA recoding event utilized by cells to enhance the information content of the genome and to regulate gene expression. The mechanismExpand
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GTPase Mechanisms and Functions of Translation Factors on the Ribosome
Abstract The elongation factors (EF) Tu and G and initiation factor 2 (IF2) from bacteria are multidomain GTPases with essential functions in the elongation and initiation phases of translation. TheyExpand
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Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria.
Initiation of mRNA translation in prokaryotes requires the small ribosomal subunit (30S), initiator fMet-tRNA(fMet), three initiation factors, IF1, IF2, and IF3, and the large ribosomal subunitExpand
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Choreography of molecular movements during ribosome progression along mRNA
During translation elongation, ribosome translocation along an mRNA entails rotations of the ribosomal subunits, swiveling motions of the small subunit (SSU) head and stepwise movements of the tRNAsExpand
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Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting
Programmed −1 ribosomal frameshifting (−1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results haveExpand
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