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Polymorphisms of the MDR1 gene in the Czech population.
There exists a marked inter-individual variability of P-glycoprotein expression and activity, which can be of clinical importance due to the large number of drugs that are substrates for theExpand
High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans.
Simultaneous HPLC determination of the analgetic agent tramadol, its major pharmacodynamically active metabolite (O-desmethyltramadol) in human plasma is described. Simple methods for the preparationExpand
Frequency of single nucleotide polymorphisms of CYP2D6 in the Czech population
CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly used drugs. Genetic polymorphisms can cause insufficient drug efficacy at usually administered doses or can be theExpand
Genetic polymorphisms of CYP2C8 in the Czech Republic.
AIM CYP2C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in metabolism of endogenous compounds. More than 20Expand
[Ursodeoxycholic acid in the treatment of primary biliary cirrhosis].
BACKGROUND Pharmacotherapy of primary biliary cirrhosis (PBC) was not resolved unequivocally so far. During the last decade bile acids are used more widely. The objective of the submitted paper wasExpand
Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms.
OBJECTIVES The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. BACKGROUND Pharmacokinetics ofExpand
Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry.
A GC-MS assay for stereoselective determination of tramadol and its pharmacologically active phase I metabolite O-desmethyltramadol in human urine was developed. Nefopam was used as internalExpand
Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone.
To prove the suitability of minipigs as experimental animal in modeling of the drug metabolism and pharmacokine-tics in man, propafenone metabolism in vitro at the microsomal level as well asExpand
Miotic action of tramadol is determined by CYP2D6 genotype.
Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to its active metabolite O-demethyltramadol (M1). Our objective was to determine the opioid effectsExpand
Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T
Dear Professor Dahlqvist, We have read with interest the articles by Pedersen et al. and Wang et al. who highlighted the importance of functional polymorphisms of CYP2D6 on the pharmacokinetics ofExpand