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Replication timing of two human common fragile sites: FRA1H and FRA2G
TLDR
The results indicate that the fragile sequences are slow replicating and that they enter G2 phase unreplicated with very high frequency, which means these regions could sometimes reach mitosis unreplicate or undercondensed and be expressed as chromosome gaps/breakages.
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Organization, nucleotide sequence, and chromosomal mapping of a tandemly repeated unit containing the four core histone genes and a 5S rRNA gene in an isopod crustacean species.
TLDR
A tandemly repeated unit of 6553 bp containing a copy of the four core histone genes H2B, H2A, H3, and H4, and also a 5S rRNA gene, was amplified by PCR from genomic DNA of the isopod crustacean Asellus aquaticus to locate the gene cluster on an inter-individually variable number of chromosomes.
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Characterization of the human common fragile site FRA2G.
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Influence of family history of dementia in the development and progression of late‐onset Alzheimer's disease
TLDR
Among the FH+ AD patients, having one or both parents affected seemed to raise the risk of earlier onset age and greater cognitive impairment than having only an affected sibling, whereas having two or more affected relatives did not.
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5S ribosomal and U1 small nuclear RNA genes: a new linkage type in the genome of a crustacean that has three different tandemly repeated units containing 5S ribosomal DNA sequences.
TLDR
Three different tandemly repeated units containing 5S rDNA were identified using PCR amplification and used as probes in fluorescent in situ hybridization (FISH) experiments to locate them on chromosomes of A. aquaticus.
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Clonal inheritance of rRNA gene activity: Cytological evidence in human cells
TLDR
Clone-specific silver staining patterns of the nucleolus organizers (NOs) were observed in clones deriving from a human diploid fibroblast culture, demonstrating the clonal inheritance of rRNA gene activity.
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Chromosome length and DNA loop size during early embryonic development of Xenopus laevis
TLDR
The quantitative analysis of chromosome length distributions at different developmental stages suggests that the shortening is timed differently in different embryonic cells, and a progressive thickening and shortening of metaphase chromosomes during development is interpreted as a strong indication that the size and number of DNA loops influence the thickness and length of the chromosomes.
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Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S.
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RNA polymerase I transcription is modulated by spatial learning in different brain regions
TLDR
It is suggested that de novo rRNA transcription is a necessary step for spatial memory consolidation, and that after learning, it occurs in several brain regions with a complex spatiotemporal dynamic.
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Sex chromosome differentiation revealed by genomic in-situ hybridization
TLDR
GISH did not reveal any sex chromosome molecular differentiation on the male and female homomorphic sex chromosome pair, and the karyotypes of these individuals were equally labelled by the male- and female-derived probe, while the heteromorphic Y chromosome showed a differentially labelled region only with themale- derived probe.
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