Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Screening of basidiomycetes for antimicrobial activities
Isolates from some species showed large differences in their ability to produce metabolites with antimicrobial activity, possibly reflecting genetic differences at the infraspecific level.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Molecular phylogenetic studies within the Xylariaceae based on ribosomal DNA sequences
The phylogenetic reconstructions showed a reasonable degree of correlation between the sequence data and the proposed morphological classification schemes only for some genera within the family, suggesting the need for further revision of the generic concepts and diagnostic characters within the Xylariaceae.
Screening of 68 species of basidiomycetes for enzymes involved in lignin degradation
Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump*
It is proposed that guggulipid is a selectivebile acid receptormodulator that regulates expression of a subset of FXR targets, and defines a novel class ofFXR ligands characterized by antagonist activities in coactivator association assays but with the ability to enhance the action of agonists onBSEP expression in vivo.
Molecular phylogenetic studies on the Diatrypaceae based on rDNA-ITS sequences
The need to revise many of the concepts usually applied to the classification of members of the Diatrypaceae family is suggested, suggesting that the multisporate asci character has appeared several times during the evolution of the group.
Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors
Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.
The Farnesoid X Receptor Controls Gene Expression in a Ligand- and Promoter-selective Fashion*
It is shown that the binding of each bile acid results in a different FXR conformations, which in turn differentially regulates expression of individual FXR targets.
Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola
The genus Zalerion is artificial; its species bear no phylogenetic relation among themselves, and a new anamorph genus and species is proposed, Glarea lozoyensis, to accommodate ATCC 20868.