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Tocilizumab in patients with severe COVID-19: a retrospective cohort study

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Pharmacokinetic Considerations for Antimicrobial Therapy in Patients Receiving Renal Replacement Therapy

The pharmacokinetic principles of CLCRRT of antimicrobial agents during the application of CVVH andCVVHDF are discussed and the most recent findings on this topic are summarised in order to understand the basis for optimal dosage adjustments of different antimacterial agents.
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The effect of pathophysiology on pharmacokinetics in the critically ill patient--concepts appraised by the example of antimicrobial agents.

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Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients.

Maintenance over time of C(min) between 2 and 7mg/L and/or of AUC₂₄ between 160 and 300 mg/L · h may be helpful in improving safety outcomes while retaining appropriate efficacy in adult patients receiving prolonged linezolid treatment.
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Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?

Some principles for the correct handling of antimicrobial dosing regimens in patients with severe sepsis and septic shock, in whom various pathophysiological conditions may significantly alter the pharmacokinetic behaviour of drugs are provided.
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Antimicrobial Therapy in Critically Ill Patients

The antimicrobial policy may further benefit from real-time application of therapeutic drug monitoring, since this practice, by tailoring exposure to the individual patient, may consequently be helpful both in improving the outcome of antimicrobial therapy and in containing the spread of resistance in the hospital setting.
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Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#

Routine TDM is recommended to be performed for aminoglycosides, beta-lactam antibiotics, linezolid, teicoplanin, vancomycin and voriconazole in critically ill patients.
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Therapeutic Drug Monitoring of Linezolid: a Retrospective Monocentric Analysis

The study suggests that the application of TDM might be especially worthwhile in about 30% of cases with the intent of avoiding either the risk of dose-dependent toxicity or that of treatment failure.
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Teicoplanin therapeutic drug monitoring in critically ill patients: a retrospective study emphasizing the importance of a loading dose.

Data obtained as part of our routine drug monitoring of teicoplanin therapy (therapeutic drug monitoring, TDM) in adult critically ill patients being treated for suspected or documented Gram-positive…
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Consensus document on controversial issues for the treatment of infections of the central nervous system: bacterial brain abscesses.

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