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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes. Expand
Variation in FTO contributes to childhood obesity and severe adult obesity
It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses. Expand
Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010
The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient. Expand
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
This study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents. Expand
High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation
The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndromeExpand
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
In addition to FTO and MC4R, genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls detected significant association of obesity with three new risk loci in NPC1, near MAF and near PTER. Expand
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants
This work mapped and examined the function of human islet cis-regulatory networks and identifies genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and shows that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains. Expand
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
It is demonstrated that SGLT2 is expressed in glucagon-secreting alpha cells of the pancreatic islets, and dapagliflozin treatment further promotes glucagon secretion and hepatic gluconeogenesis in healthy mice, thereby limiting the decrease of plasma glucose induced by fasting. Expand
Hypocalcemia following Thyroid Surgery: Incidence and Prediction of Outcome
It was found that patients carried a high risk for permanent hypoparathyroidism if fewer than threeParathyroid glands were preserved in situ during surgery or the early serum parathyroid hormone level was ≤ 12 pg/ml, the delayed serum calcium levels ≤ 8 mg/dl, or the delayed Sera phosphorus level ≥ 4mg/dl under oral calcium therapy. Expand
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
The data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway and show MT2 expression in human pancreatic islets and beta cells. Expand