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Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension
Vascular smooth muscle cell (VSMC) phenotypic plasticity has a critical role in the pathophysiology of arterial remodeling in essential hypertension. MicroRNAs are emerging as potential biomarkersExpand
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Left Ventricular Function and Cardiopulmonary Performance Following Surgical Treatment of Morbid Obesity
Background: It is well established that morbid obesity affects the respiratory system and the diastolic function of the heart. During exercise, cardiopulmonary reserve is exhausted because ofExpand
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MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage.
MicroRNAs (miRs), as essential gene expression regulators, modulate cardiovascular development and disease and thus they are emerging as potential biomarkers and therapeutic targets in cardiovascularExpand
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Interaction between platelets and endothelium: from pathophysiology to new therapeutic options.
Platelets were traditionally considered to purely have a role in the maintenance of haemostasis. Recently their role in vasomotor function, inflammation and atherosclerosis has been veryExpand
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Low Levels of MicroRNA‐21 Are a Marker of Reduced Arterial Stiffness in Well‐Controlled Hypertension
MicroRNAs (miRNAs) play a crucial role in myocardial and vascular remodeling and have emerged as potential diagnostic and prognostic biomarkers or as therapeutic targets. The authors aimed toExpand
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MicroRNAs in Peripheral Mononuclear Cells as Potential Biomarkers in Hypertensive Patients With Heart Failure With Preserved Ejection Fraction
BACKGROUND MicroRNAs (miRs) regulate gene expression and play an important role in ventricular and vascular remodeling. However, there are limited data regarding their role in heart failure withExpand
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Anaesthesia and the QT intervalEffects of isoflurane and halothane in unpremedicated children
The effects of isoflurane and halothane on the QT interval were investigated during induction of anaesthesia. Fifty‐one unpremedicated, ASA grade 1 children were studied. Anaesthesia was induced withExpand
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Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies
Cardiac muscle contraction occurs through an interaction of the myosin head with the actin filaments, a process which is regulated by the troponin complex together with tropomyosin and is Ca2+Expand
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Asymptomatic papillary fibroelastoma of the Aortic valve in a young woman - a case report
Echocardiography represents an invaluable diagnostic tool for the detection of intracardiac masses while simultaneously provides information about their size, location, mobility and attachment siteExpand
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Early cardiac gene transcript levels in peripheral blood mononuclear cells in patients with untreated essential hypertension
Objectives To assess the expression of early cardiac genes, implicated in the hypertrophic growth response of the adult heart, in peripheral blood mononuclear cells in patients with essentialExpand
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