• Publications
  • Influence
Subspecific origin and haplotype diversity in the laboratory mouse
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught miceExpand
  • 381
  • 25
  • PDF
Female meiosis drives karyotypic evolution in mammals.
Speciation is often accompanied by changes in chromosomal number or form even though such changes significantly reduce the fertility of hybrid intermediates. We have addressed this evolutionaryExpand
  • 194
  • 16
  • PDF
C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response
Not All Mice Are Equal Different laboratories often use different strains of inbred animals, but one cannot make behavioral comparisons and assume that their reaction to interventions willExpand
  • 140
  • 12
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics
Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources were generatedExpand
  • 205
  • 11
  • PDF
Analyses of Allele-Specific Gene Expression in Highly Divergent Mouse Crosses Identifies Pervasive Allelic Imbalance
Complex human traits are influenced by variation in regulatory DNA through mechanisms that are not fully understood. Because regulatory elements are conserved between humans and mice, a thoroughExpand
  • 162
  • 11
  • PDF
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signaling
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is notExpand
  • 163
  • 10
Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross
Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmentalExpand
  • 151
  • 9
  • PDF
The Mouse Universal Genotyping Array: From Substrains to Subspecies
Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks. We have developed the third generation of theExpand
  • 119
  • 7
  • PDF
High-Resolution Sex-Specific Linkage Maps of the Mouse Reveal Polarized Distribution of Crossovers in Male Germline
Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation inExpand
  • 62
  • 7
  • PDF
Genetic architecture of voluntary exercise in an advanced intercross line of mice.
Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations andExpand
  • 68
  • 3
  • PDF
...
1
2
3
4
5
...