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DNA damage and chromosomal aberrations in various types of male factor infertility.
TLDR
Infertile men are prone to have DNA damage; the nature and level of DNA damage varies and is associated with semen parameters; the presence of double minute chromosomes alone is associatedWith increased double-stranded breaks and abnormal sperm concentration. Expand
INDUCTION OF CYP1A AND CYP2-MEDIATED ARACHIDONIC ACID EPOXYGENATION AND SUPPRESSION OF 20-HYDROXYEICOSATETRAENOIC ACID BY IMIDAZOLE DERIVATIVES INCLUDING THE AROMATASE INHIBITOR VOROZOLE
TLDR
Increased CYP1A activity in mouse Hepa 1-6 and human HepG2 cells by vorozole and other imidazole derivatives demonstrated applicability of the findings to mammalian cells, suggesting that changes in P450-dependent arachidonic acid metabolism may be a new source of side effects for drugs that induce CYP2. Expand
Supplementation of melatonin protects human lymphocytes in vitro from the genotoxic activity of melphalan.
TLDR
The results imply that MLT may be proved useful in reducing some of the toxic effects associated with certain classes of chemotherapeutic agents and other chemical and physical mutagens and carcinogens, acting both as an antioxidant-radical scavenger and a protective mechanism against cellular damage due to exposure to free radical-producing agents. Expand
The Effects of Apigenin on the Expression of Fas/FasL Apoptotic Pathway in Warm Liver Ischemia-Reperfusion Injury in Rats
TLDR
The effects of apigenin in the Fas/FasL mediated pathway of apoptosis, in the hepatic ischemia-reperfusion, seem to have a protective result on the liver cell. Expand
The mutagenic potential of vitamin C on human lymphocytes and native nucleic acids
As an antioxidant, Vit C is involved in a number of biological processes such as cancer resistance, reduction of DNA damage and chromosomal breakage caused by several carcinogens and other agentsExpand
Mycotoxins’ Activity at Toxic and Sub-Toxic Concentrations: Differential Cytotoxic and Genotoxic Effects of Single and Combined Administration of Sterigmatocystin, Ochratoxin A and Citrinin on the
TLDR
Results for the first time describe that STER alone or in combination with OTA and/or CTN share a cytotoxic and cytogenetic potential even at picoMolar concentrations on human hepatoma cells in vitro. Expand
Evidence of increased chromosomal instability in infertile males after exposure to mitomycin C and caffeine.
TLDR
It is illustrated that infertile men, compared with fertile ones, demonstrated a statistically significant DNA instability in peripheral blood lymphocytes after being exposed simultaneously to MMC and CAF. Expand
Cytoprotective activity of amifostine on cultured human lymphocytes exposed to irinotecan.
TLDR
The cytoprotective efficacy of amifostine (ethyol, ETH) against chromosomal damage induced by this drug on cultured peripheral human lymphocytes is examined to assess the predicted benefits from ETH in patients receiving CAM. Expand
Antineoplastic and cytogenetic effects of chlorpromazine on human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo
TLDR
High chlorpromazine concentrations increase chemotherapeutic effectiveness of mitomycin C and need to be tested along with antineoplastic agents in vitro for its synergistic action so as to evaluate a potential clinical application. Expand
Bacterial translocation in a rat model of large volume hepatic radiofrequency ablation.
TLDR
The intestinal mucosa barrier was disrupted as suggested by ileal mucosal atrophy, increased crypt apoptosis, and induction of oxidative stress as well as endotoxemia and translocation of intestinal bacteria to proximal and distal to the intestine organs at both the early and late post-RFA periods. Expand
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