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Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils.
It is shown that E GCG amyloid remodeling activity in vitro is dependent on auto-oxidation of the EGCG, and insights into the molecular mechanism of action of EGCGs provide boundary conditions for exploring amyloids remodeling in more detail. Expand
A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation*
It is demonstrated that a metabolic shift toward the pentose phosphate pathway (PPP) is necessary for NET release because glucose-6-phosphate dehydrogenase (G6PD), an important enzyme from PPP, fuels NADPH oxidase with NADPH to produce superoxide and thus induce NETs. Expand
Role of nitric oxide in the response of Saccharomyces cerevisiae cells to heat shock and high hydrostatic pressure.
The hypothesis that an increase in intracellular NO concentration leads to stress protection was supported and induction of NO synthase was isoform-specific and dependent on the metabolic state of the cells and the stress response pathway. Expand
The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers*
The solution structure of CDNF was determined and it was demonstrated that it was able to protect dopaminergic neurons against injury caused by α-synuclein oligomers, which strengthens the therapeutic relevance of using CDNF to treat neurodegenerative diseases. Expand
Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase*
Data reveal that release of NETs, so far described to be elicited by pathogens, can also be triggered by amyloid fibrils, which might be crucial for the production of toxic species derived from fibril fragmentation. Expand
Inactivation of Colletotrichum gloeosporioides spores by high hydrostatic pressure combined with citral or lemongrass essential oil.
The use of high hydrostatic pressure and plant essential oils as an alternative control for fruit diseases is suggested. Expand
Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis
It is shown that A25T fibrils act as pro-inflammatory agents in OA, activating microglia and causing neuronal damage, and could be prevented by minocycline treatment. Expand
Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes
It is shown that Aβ fibrils adsorb to the plastic surface of multiwell plates and Eppendorf tubes in the presence of biological extracts, and it is concluded that the interpretation of the kinetic fibril disaggregation assay data is invalid when used as evidence for a disaggregase activity. Expand
Induction of baroresistance by hydrogen peroxide, ethanol and cold-shock in Saccharomyces cerevisiae.
The acquisition of tolerance to high hydrostatic pressure of 220 MPa (HHP) in response to a 0.4 mM hydrogen peroxide, 6% ethanol and cold-shock (10 degrees C) pretreatment for different lengths ofExpand
Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that
The results revealed the in vitro characterization of TTR aggregation in a biologically relevant environment, opening new avenues of investigation into the molecular mechanisms of LA, and identified novel proteins, such as blood coagulation proteins. Expand