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Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio)
Diabetes mellitus, which causes hyperglycemia, affects the central nervous system and can impairs cognitive functions, such as memory. The aim of this study was to investigate the effects ofExpand
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Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish
The mTORC1 complex integrates different inputs from intracellular and extracellular signals to control various cellular processes. Therefore, any disruption in the mTORC1 pathway could promoteExpand
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Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.
Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. InExpand
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Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio).
Adenosine receptors are the most important biochemical targets of caffeine, a common trimethylxanthine found in food and beverages. Adenosine plays modulatory action during the development throughExpand
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Arginine exposure alters ectonucleotidase activities and morphology of zebrafish larvae (Danio rerio)
Hyperargininemia is an inborn error of metabolism (IEM) characterized by tissue accumulation of arginine (Arg). Mental retardation and other neurological features are common symptoms inExpand
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Tolerance to seizure induced by kainic acid is produced in a specific period of zebrafish development
During brain development, the electrical disturbance promoted by a seizure can have several consequences, because it can disturb a set of steps extremely regulated needed to the correct brainExpand
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Chapter 22 – Caffeine
Caffeine, a component of coffee, soft drinks, and chocolate, is widely consumed and considered harmless, although it has powerful effects on a number of organs, systems, and behavior. Caffeine, inExpand
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Evaluation of age-dependent response to NMDA receptor antagonism in zebrafish.
Imbalances in glutamatergic signaling have been proposed as the cause of several neurological disturbances. The use of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, to mimic features ofExpand
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Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish
Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of development. Exposure to caffeine, a non-specific blocker of adenosineExpand
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The influence of temperature on adult zebrafish sensitivity to pentylenetetrazole
Pentylenetetrazole (PTZ) is one of the most valuable drugs used to induce seizure-like state in zebrafish especially considering the pharmacological screening for anticonvulsants and the study ofExpand
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