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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
TLDR
These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress, and breeding to NRF2-deficient mice reversed the phenotypic Keap 1 deficiencies. Expand
Epidermal sphingomyelins are precursors for selected stratum corneum ceramides.
TLDR
Two epidermal SM, SM-1 and SM-3, are important precursors of two corresponding Cer in mammalian SC, that is, Cer 2 and Cer 5, but other Cerspecies, including the omega-hydroxy Cer species, do not derive from SM. Expand
Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan
TLDR
It is noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan, which may be a new sign of diphenylarsinic acid poisoning, and mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. Expand
Human epidermal glucosylceramides are major precursors of stratum corneum ceramides.
TLDR
Structural analysis of glucosylceramides revealed that human epidermal glycosphingolipids display a unique lipid profile that is rich in very long chain hydroxylated (alpha- and omega-hydroxy) fatty acids and phytosphingosine. Expand
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.
TLDR
The data indicate that genetic differences in transcriptional activity of the IL4 gene influence AD predisposition, particularly in Japanese, because of a high frequency of the T allele. Expand
Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update
TLDR
The nationwide survey of Japanese patients with malignant skin tumors from 1987 to 2001 showed that the most prevalent skin tumor was basal cell carcinoma, which increased year by year, followed by squamous cell carcinomas, and then by malignant melanoma. Expand
Promoter methylation profiling of 30 genes in human malignant melanoma
TLDR
These profiles showed that both aberrant methylation and demethylation occur widely in human melanomas. Expand
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
TLDR
A genome-wide search using methylation-sensitive representational difference analysis found CGIs in putative promoter regions of 34 genes, and among these genes, Peroxiredoxin 2 (PRDX2) was expressed in normal melanocytes, and its expression was lost in melanomas with methylation. Expand
Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis.
TLDR
It is found that UVA irradiation, but not UVB, causes nuclear translocation and accumulation of NRF2 by a factor of 6.5 as compared with unirradiated controls, and the Nrf2-Keap1 pathway plays an important role in the protection of the skin against UVA radiation. Expand
ANCA‐associated vasculitis and lupus‐like syndrome caused by methimazole
TLDR
The leg ulcers dramatically improved after methimazole was withdrawn and leucocytopenia and the immunological abnormalities soon laded, and this is the first report describing ANCA‐associated vasculitis caused by methicazole. Expand
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