Share This Author
Evolutionary Dynamics of Vibrio cholerae O1 following a Single-Source Introduction to Haiti
Intensive mutational processes can account for virtually all of the observed genetic polymorphism, with no demonstrable contribution from horizontal gene transfer (HGT), and no evidence that environmental strains have played a role in the evolution of the outbreak strain.
Phylogenomic Analysis of the Gammaproteobacterial Methanotrophs (Order Methylococcales) Calls for the Reclassification of Members at the Genus and Species Levels
- F. Orata, Jan P. Meier-Kolthoff, Dominic Sauvageau, L. Stein
- BiologyFront. Microbiol.
- 19 December 2018
The order Methylococcales constitutes the methanotrophs – bacteria that can metabolize methane, a potent greenhouse gas, as their sole source of energy. These bacteria are significant players in the…
The 2010 Cholera Outbreak in Haiti: How Science Solved a Controversy
The article focuses on the genetic basis of the spread of cholera in Haiti which clarifies both the climatic and human transmission hypotheses explaining the origin of the disease after the January…
A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules
The diversity of GIs circulating in natural V. cholerae populations is highlighted and GIs with VPI-1 recombination characteristics are identified as a propagator of CRISPR-Cas and T6SS modules.
The Dynamics of Genetic Interactions between Vibrio metoecus and Vibrio cholerae, Two Close Relatives Co-Occurring in the Environment
- F. Orata, P. Kirchberger, R. Méheust, E. J. Barlow, C. Tarr, Y. Boucher
- BiologyGenome biology and evolution
- 1 October 2015
The virulence factors of V. cholerae are therefore both more ancient and more widespread than previously believed, and high interspecies recombination in the core genome, which has been detected in 24% of the single-copy core genes, including genes involved in pathogenicity.
A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera
This work introduces a core genome multilocus sequence typing scheme for V. cholerae, a bacterium abundant in marine and freshwater environments and the etiologic agent of cholera, and confirms the South Asian origin of modern epidemics and identified clustering affinity among sublineages of environmental isolates from the same geographic origin.
A Small Number of Phylogenetically Distinct Clonal Complexes Dominate a Coastal Vibrio cholerae Population
- P. Kirchberger, F. Orata, Y. Boucher
- Biology, Environmental ScienceApplied and Environmental Microbiology
- 1 July 2016
By extensive sampling in a geographically restricted location in the United States, it is found that most cells of a V. cholerae population belong to only a small number of strains, making it possible that more virulent strains could stochastically rise to large numbers, allowing for infection to occur.
Roseobacters in a Sea of Poly- and Paraphyly: Whole Genome-Based Taxonomy of the Family Rhodobacteraceae and the Proposal for the Split of the “Roseobacter Clade” Into a Novel Family,…
- Kevin Y. H. Liang, F. Orata, Y. Boucher, Rebecca J. Case
- BiologyFrontiers in Microbiology
- 25 June 2021
This study performs whole-genome phylogenetic and genotypic analyses combined with a meta-analysis of phenotypic data to review taxonomic classifications of 331 type strains within the Rhodobacteraceae family and proposes to move the roseobacter clade into a new family.
Complete Genome Sequence of Methylomonas denitrificans Strain FJG1, an Obligate Aerobic Methanotroph That Can Couple Methane Oxidation with Denitrification
The sequenced genome of FJG1 reveals the presence of genes that encode methane, methanol, formaldehyde, and formate oxidation, consistent with the ability of F JG1 to couple denitrification with methane oxidation.
The out-of-the-delta hypothesis: dense human populations in low-lying river deltas served as agents for the evolution of a deadly pathogen
It is proposed that the unique human and physical geography of low-lying river deltas made it possible for an environmental bacterium to evolve into a deadly human pathogen.