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- Publications
- Influence
In vivo rodent erythrocyte micronucleus assay.
- M. Hayashi, R. Tice, +7 authors H. Shimada
- Biology, Medicine
- Mutation research
- 1 June 1994
The following summary represents a consensus of the working group except where noted. The items discussed are listed in the order in which they appear in the OECD guideline (474) for easy reference.… Expand
Once-Daily Dosing in Dogs Optimizes Daptomycin Safety
- F. Oleson, C. Berman, J. Kirkpatrick, K. Regan, J. Lai, F. Tally
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 November 2000
ABSTRACT Daptomycin is a novel lipopeptide antibiotic with potent bactericidal activity against most clinically important gram-positive bacteria, including resistant strains. Daptomycin has been… Expand
Daptomycin: a novel agent for Gram-positive infections.
- F. Tally, M. Zeckel, +4 authors F. Oleson
- Medicine
- Expert opinion on investigational drugs
- 1 August 1999
The alarming increase in the incidence of Gram-positive infections, including those caused by resistant bacteria, has sparked renewed interest in novel antibiotics. One such agent is daptomycin, a… Expand
Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.
- B. Eisenstein, F. Oleson, R. H. Baltz
- Medicine
- Clinical infectious diseases : an official…
- 1 February 2010
Daptomycin has been approved and successfully launched for the treatment of complicated skin and skin-structure infections caused by gram-positive pathogens [1] and bacteremia and right-sided… Expand
A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties.
- K. Reimann, W. Lin, +12 authors L. Burkly
- Biology, Medicine
- AIDS research and human retroviruses
- 20 July 1997
Certain monoclonal antibodies (MAbs) directed against CD4 can efficiently block HIV-1 replication in vitro. To explore CD4-directed passive immunotherapy for prevention or treatment of AIDS virus… Expand
OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics.
- Cindy L Berman, S. Barros, +6 authors Z. Sobol
- Chemistry, Medicine
- Nucleic acid therapeutics
- 11 April 2016
The Oligonucleotide Safety Working Group subcommittee on genotoxicity testing considers therapeutic oligonucleotides (ONs) unlikely to be genotoxic based on their properties and on the negative… Expand
Single‐strand breaks, chromosome aberrations, sister‐chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics
- J. Mäki-Paakkanen, H. Norppa, S. Walles, S. Osterman-Golkar, F. Oleson
- Biology, Medicine
- Environmental and molecular mutagenesis
- 1991
Chromosome aberrations (CA), micronuclei (MN, cytokinesis‐block [CB] method), and sister‐chromatid exchanges (SCE) were analysed in blood lymphocytes of 17 workers and 17 control subjects. The mean… Expand
Gastric Enterochromaffin-Like Cell Hyperplasia and Neoplasia in the Rat: An Indirect Effect of the Histamine H2-Receptor Antagonist, BL-6341
- R. Hirth, L. D. Evans, R. Buroker, F. Oleson
- Chemistry, Medicine
- Toxicologic pathology
- 1 February 1988
Oral administration of BL-6341 hydrochloride, a long-acting histamine H2-receptor antagonist, to rats for 2 years at doses of 10, 55 or 300 mg/kg/day resulted in several changes in the fundic… Expand
Immunomodulation by LFA3TIP, an LFA-3/IgG1 fusion protein: cell line dependent glycosylation effects on pharmacokinetics and pharmacodynamic markers.
- W. Meier, A. Gill, +7 authors P. Hochman
- Chemistry, Medicine
- Therapeutic immunology
- 1 June 1995
LFA3TIP, a fusion protein comprised of the first extracellular domain of LFA-3 fused to the hinge, CH2, and CH3 domains of human IgG1 inhibits responses of human and non-human primate T cells in… Expand
Interaction of daptomycin with two recombinant thromboplastin reagents leads to falsely prolonged patient prothrombin time/International Normalized Ratio results
- P. S. Webster, F. Oleson, +7 authors W. Martone
- Medicine
- Blood coagulation & fibrinolysis : an…
- 1 January 2008
A cluster of patients experiencing elevations of International Normalized Ratio without clinical bleeding in temporal association with daptomycin therapy was identified during postmarketing safety… Expand
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