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Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation.
- B. Bodosi, J. Gardi, I. Hajdu, É. Szentirmai, F. Obál, J. Krueger
- Biology, PsychologyAmerican journal of physiology. Regulatory…
- 1 November 2004
A strong relationship between feeding and the diurnal rhythm of leptin is suggested and that feeding also fundamentally modulates the di nighttime rhythm of ghrelin.
The Role of Cytokines in Physiological Sleep Regulation
- J. Krueger, F. Obál, Jidong Fang, T. Kubota, P. Taishi
- BiologyAnnals of the New York Academy of Sciences
- 1 March 2001
It is posited that these GFs are produced in response to neural activity and affect input‐output relationships within the neural circuits where they are produced, thereby inducing a local state shift.
Biochemical regulation of non-rapid-eye-movement sleep.
There is a third group of substances whose significance in sleep regulation is less clear but for which there are two or more lines of evidence suggesting that they may have a role in modulating non-REM sleep (NREMS).
Brain and core temperatures and peripheral vasomotion during sleep and wakefulness at various ambient temperatures in the rat
The paradoxical peripheral vasomotion duringREMS supports previous suggestions on severe thermoregulatory impairment during REMS in other species and is suggested that the suppression of sleep in the cold and the enhancement of NREMS in the heat promote thermoreGulation.
GHRH and sleep.
Sleep in mice with nonfunctional growth hormone-releasing hormone receptors.
- F. Obál, J. Alt, P. Taishi, J. Gardi, J. Krueger
- Biology, MedicineAmerican journal of physiology. Regulatory…
The results suggest that GH promotes REMS whereas G HRH stimulates NREMS via central GHRH-Rs and that GHRh is involved in the mediation of the sleep effects of ghrelin and somatostatin.
Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation.
- F. Obál, L. Payne, M. Opp, P. Alföldi, L. Kapás, J. Krueger
- Biology, MedicineThe American journal of physiology
- 1 November 1992
Electroencephalographic (EEG) slow-wave activity, characterized by EEGslow-wave amplitudes, was reduced after GHRH-ab during both the light and the dark cycles, and after sleep deprivation (+IgG), a prompt increase in EEG slow- wave activity (power density analysis) and late increases in NREMS and REMS durations were found.
Intrapreoptic Microinjection of GHRH or Its Antagonist Alters Sleep in Rats
- Jianyi Zhang, F. Obál, Tong Zheng, Jidong Fang, P. Taishi, J. Krueger
- BiologyThe Journal of Neuroscience
- 15 March 1999
The results indicate that the preoptic area mediates the sleep-promoting activity of GHRH.
Humoral Regulation of Sleep.
- J. Krueger, Jidong Fang, M. K. Hansen, Jianyi Zhang, F. Obál
- Biology, MedicineNews in physiological sciences : an international…
- 1 August 1998
Cytokines and hormones, including interleukin-1, tumor necrosis factor, growth hormone-releasing hormone, vasoactive intestinal polypeptide and prolactin, are involved in sleep regulation. These…