• Publications
  • Influence
Onset, natural history and outcome in idiopathic adult motor neuron disease
Cases of adult-onset idiopathic motor neuron disease (MND) identified from January 1970 through December 1986 were studied in a defined area of California. The patients were followed prospectivelyExpand
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Amyotrophic lateral sclerosis severity scale.
The amyotrophic lateral sclerosis (ALS) severity scale has been developed to provide an ordinal staging system and a means of rapid functional assessment for patients with ALS. The scale allows anExpand
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Effect of recombinant human insulin-like growth factor-I on progression of ALS
The objective of this study was to investigate the safety and efficacy of recombinant human insulinlike growth factor-I (rhIGF-I) in the treatment of sporadic ALS. A double-blind, placebo-controlled,Expand
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Spirometry in amyotrophic lateral sclerosis.
Clinical evaluation and pulmonary function tests were performed in 218 patients with motor neuron disease, mainly amyotrophic lateral sclerosis (ALS). Serial studies were obtained in 103 patients, inExpand
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An electromyographic study of induced and spontaneous muscle cramps.
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Distribution of alpha interferon in serum and cerebrospinal fluid after systemic administration
After intravenous infusion of recombinant leukocyte interferon (rIFN‐αA) to four subjects with an indwelling reservoir, serial serum and cerebrospinal fluid samples were taken over 48 hr and wereExpand
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Amyotrophic lateral sclerosis. Impairment of neuromuscular transmission.
Neuromuscular transmission was studied in the ulnar-hypothenar group in 55 patients with amyotrophic lateral sclerosis. A decremental response was found in 67.0%. The decrement was larger and presentExpand
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Psychological Characteristics of Patients with Amyotrophic Lateral Sclerosis (ALS)
&NA; Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations,Expand
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Enkephalin-induced depression of single neurons in brain areas with opiate receptors--antagonism by naloxone.
Enkephalin, applied microiontophoretically, depressed spontaneous and glutamate-induced firing of single neurons in frontal cortex, caudate nucleus, and periaqueductal gray matter, where enkephalinExpand
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