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Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140.
MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAsExpand
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Two classes of small antisense RNAs in fungal RNA silencing triggered by non‐integrative transgenes
Transformation of Mucor circinelloides with self‐replicative plasmids containing a wild‐type copy of the carotenogenic gene carB causes silencing of the carB function in 3% of transformants. GenomicExpand
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Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level.
mRNA profiling is routinely used to identify microRNA targets, however, this high-throughput technology is not suitable for identifying targets regulated only at protein level. Here, we haveExpand
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Antifungal drug resistance evokedvia RNAi-dependent epimutations
Microorganisms evolve via a range of mechanisms that may include or involve sexual/parasexual reproduction, mutators, aneuploidy, Hsp90 and even prions. Mechanisms that may seem detrimental can beExpand
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Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides
Endogenous short RNAs (esRNAs) play diverse roles in eukaryotes and usually are produced from double-stranded RNA (dsRNA) by Dicer. esRNAs are grouped into different classes based on biogenesis andExpand
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A negative regulator of light-inducible carotenogenesis in Mucor circinelloides
Abstract. Mucor circinelloides responds to blue light by activating carotene biosynthesis. Wild-type strains grown in darkness contain minimal amounts of β-carotene because of the low levels ofExpand
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Biogenesis of Y RNA‐derived small RNAs is independent of the microRNA pathway
Y RNAs are approximately 100 nucleotide long conserved cytoplasmic non‐coding RNAs, which produce smaller RNA fragments during apoptosis. Here we show that these smaller RNA molecules are alsoExpand
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The RNAi machinery controls distinct responses to environmental signals in the basal fungus Mucor circinelloides
BackgroundRNA interference (RNAi) is a conserved mechanism of genome defence that can also have a role in the regulation of endogenous functions through endogenous small RNAs (esRNAs). In fungi,Expand
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Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres
Centromeres are rapidly evolving across eukaryotes, despite performing a conserved function to ensure high fidelity chromosome segregation. CENP-A chromatin is a hallmark of a functional centromereExpand
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Mutants defective in a Mucor circinelloides dicer-like gene are not compromised in siRNA silencing but display developmental defects.
Dicer proteins are ribonuclease III enzymes that process double stranded RNA precursors into small RNAs categorized as small interfering RNAs (siRNAs) or microRNAs (miRNAs), which suppress geneExpand
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