Studies On The Use Of “Slimax”, A Chinese Herbal Mixture, In The Treatment Of Human Obesity
- V. Ignjatovic, E. Ogru, M. Heffernan, R. Libinaki, Y. Lim, F. Ng
- BiologyPharmaceutical Biology
- 1 January 2000
Treatment with Slimax resulted in a significant decrease in parameters such as body weight, waist and hip circumference, and Body Mass Index, in all subjects tested.
Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats.
- F. Ng, W. J. Jiang, R. Gianello, S. Pitt, P. Roupas
- BiologyJournal of Molecular Endocrinology
- 1 December 2000
Synthetic AOD9401 has the potential to be developed into a therapeutic agent for the control of obesity and mimicked the effect of the intact growth hormone on diacylglycerol release in adipocytes.
The conformational and biological analysis of a cyclic anti-obesity peptide from the C-terminal domain of human growth hormone.
Comparison of the conformation of this peptide with residues 177-191 in the native hGH protein X-ray crystal structure indicates that the synthetic peptide retains some structural similarity to the intact protein.
Insulin Potentiating Action of a Peptide Fraction from Human Urine
The urinary preparation potentiates the action of insulin in the isolated rat diaphragm and in rabbits and rats, but the latter animals are far more sensitive to its action.
Structure and synthesis of biologically active peptides derived from pituitary growth hormone.
Synthesis and evaluation of constrained peptide analogues related to the N-terminal region of human growth hormone.
The synthesis and incorporation of two different isomeric gamma-lactam structures into peptide analogues related to hGH [6-13] were found to be more potent and longer lasting than the aspartimide peptide analogue.
Insulin Potentiating Action of Synthetic Peptides Relating to the Amino Terminal Sequence of Human Growth Hormone
The results show that large doses of the active peptide HGH 1-15 do not increase the degree of lowering of blood glucose, but prolong the effect of the peptide and depress plasma immunoreac-tive insulin (IRI) in rabbits.
The Minimal Amino Acid Sequence of the Insulin-potentiating Fragments of Human Growth Hormone: Its Mechanism of Action
- F. Ng, J. Bornstein, C. Pullin, J. Bromley, S. Lance Macaulay
- Biology, ChemistryDiabetes
- 1 October 1980
Results strongly indicate that the insulin- potentiating action of the active peptides is to increase the binding of insulin to specific receptors and thus modulate the action of glycogen synthase and phosphorylase, producing hypoglycemia as the result of increased glycogen storage in liver, muscle, and adipose tissue.
Hypoglycaemic activity of an analogue of human growth hormone [6-13] incorporating a D-Ala-Pro dipeptide unit
Insulin-potentiating action of human growth hormone. Synthesis and activity of N-terminal fragments.
- C. Pullin, J. A. Harcourt, F. Ng, J. Bornstein
- Biology, ChemistryInternational journal of peptide & protein…
- 12 January 2009
The data indicates that extension of hGH(9-13) at its N-terminus is required for in vitro activity, and the insulin-potentiating activity of these peptides is reported.