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Biosynthesis, Maturation, Release, and Degradation of Neurotensin and Neuromedin N
The cloning in 1987 of the neurotensin (NT) precursor' has revealed that it contains several possible dibasic maturation sites, and therefore has the capability to generate a number of differentExpand
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The characterization and regional distribution of neuromedin N-like immunoreactivity in rat brain using a highly sensitive and specific radioimmunoassay. Comparison with the distribution of
Neuromedin N is a hexapeptide that shares a 4 amino acid homology with the C-terminus of neurotensin and exhibits neurotensin-like effects in the central nervous system. Both peptides were recentlyExpand
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PC12 cells can be induced to produce, but do not process, the neurotensin/neuromedin N precursor
Neurotensin and neuromedin N are two biologically active, related peptides that are encoded in the same precursor molecule. In the rat, the precursor consists of a 169-residue polypeptide containingExpand
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Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat—II. Immunohistochemical localization of maturation products
The neurotensin/neuromedin N precursor molecule possesses four lysine-arginine dibasic residues which represent potential sites of cleavage by proteolytic maturation enzymes. As shown in theExpand
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Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat—I. Biochemical characterization of maturation products
Neurotensin and neuromedin N are two biologically active related peptides which are encoded in the same precursor molecule. In the rat, the precursor consists of a 169-residue polypeptide containingExpand
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Biosynthese et maturation du precurseur commun de la neurotensine et de la neuromedine n chez le rat
La neurotensine (nt) est un tridecapeptide dont le role de neuromediateur dans le systeme nerveux central et peripherique des mammiferes est maintenant bien etabli. Ce peptide est implique dans desExpand
Immunohistochemical Detection of Pro‐Neurotensin/Neuromedin N Processing Intermediates in Rat Brain
The 170-amino-acid neurotensin (NT)/neuromedin N (NN) precursor possesses four pairs of lysine-arginine dibasic residues. The existence of these dibasics, which represent potential cleavage sites forExpand
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