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Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma.
Activating mutations of anaplastic lymphoma kinase (ALK) have been identified as important players in neuroblastoma development. Our goal was to evaluate the significance of overall ALK activation inExpand
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New Ifosfamide Analogs Designed for Lower Associated Neurotoxicity and Nephrotoxicity with Modified Alkylating Kinetics Leading to Enhanced in Vitro Anticancer Activity
Ifosfamide is a well known prodrug for cancer treatment with cytochrome P450 metabolism. It is associated with both antitumor activity and toxicities. Isophosphoramide mustard is the bisalkylatingExpand
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Iron Overload Exacerbates Busulfan-Melphalan Toxicity Through a Pharmacodynamic Interaction in Mice
PurposeBusulfan-melphalan high-dose chemotherapy followed by autologous stem cell transplantation is an essential consolidation treatment of high-risk neuroblastoma in children. Main treatmentExpand
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Theobromine Content in Cocoa Pod Husk (Theobroma cacao) Fermented by Aspergillus spp. in Different of Chop Sizes and Fermentation Times
Theobromine is one of alkaloid in cocoa pod husk (CPH). Fresh CPH has high theobromine content reach 0.40% (400.000 ppm) which is fresh CPH portion in ruminant ration more than 30% to be affected ofExpand
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New ifosfamide analogs aiming less neurotoxicity and less nephrotoxicity
5591 Ifosfamide (IFM) is an useful prodrug with cytochrome P450 metabolisation associated to both antitumor activity and toxicities such as urotoxicity, nephrotoxicity and neurotoxicity.Expand
Greenhouse Gas Emission (GHG) from ruminant on 2016 at Central Sulawesi Province
Ruminant is the one of sectors livestock that contribute to increase global warming originates manure and animal eructation. Ruminant sector accounted for carbon dioxide (CO2), methane (CH4), nitrousExpand
Role of ALK activation in the development and maintenance of the neoplastic phenotype in neuroblastoma.
10008 Background: Activating mutations of the Anaplastic Lymphoma Kinase (ALK) receptor could be responsible for most familial neuroblastoma cases and for up to 15% of somatic cases. The objective ofExpand
Effect of Fermented Cocoa Pod Husk Level in Concentrate on Etawah Grade Semen Quality
The purpose of study was to determine the effect of fermented CPH supplementation level in concentrate toward semen quality of Etawah Grade Buck (EGB). This research was conducted from August toExpand
Iron increases busulfan toxicity in vivo and in vitro
1565 Busulfan is an alkylating agent widely used in combination high-dose chemotherapy regimens followed by allogeneic or autologous haematopoietic stem cell transplantation (HSCT). The effect ofExpand