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Cryptococcus neoformans Senses CO2 through the Carbonic Anhydrase Can2 and the Adenylyl Cyclase Cac1
TLDR
The data reveal Can2 to be the main carbonic anhydrase and suggest a physiological role for bicarbonate during C. neoformans growth, which is optimal at physiological pH.
PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression
TLDR
PHR1 and PHR2 represent a novel pH-balanced system of functional homologs required for C. albicans to adapt to environments of diverse pH.
The Quorum-Sensing Molecules Farnesol/Homoserine Lactone and Dodecanol Operate via Distinct Modes of Action in Candida albicans
TLDR
It is shown that farnesol and 3-oxo-C12-homoserine lactone, a quorum-sensing molecule secreted by Pseudomonas aeruginosa, block hyphal development by affecting cAMP signaling; they both directly inhibited the activity of the Candida adenylyl cyclase, Cyr1p, and dodecanol exerted its effects through a mechanism involving the C. albicans hyphal repressor, Sfl1p.
The pH of the Host Niche Controls Gene Expression in and Virulence of Candida albicans
TLDR
The results suggest that the pH of the infection site regulates the expression of genes essential to survival within that niche, and implies that the study of environmentally regulated genes may provide a rationale for understanding the pathobiology of C. albicans.
Inactivation of Transcription Factor Gene ACE2 in the Fungal Pathogen Candida glabrata Results in Hypervirulence
TLDR
It is demonstrated that the Candida glabrata homolog of the Saccharomyces cerevisiae transcription factor gene ACE2 encodes a function that mediates virulence in a novel way, the first virulence-moderating gene to be described for a Candida species.
The KEX2 gene of Candida glabrata is required for cell surface integrity
TLDR
In an in vitro model of oral candidosis, kex2 mutants showed reduced tissue damage in the presence of itraconazole compared with the control infections, suggesting that Kex2 is involved in the processing of proteins that are essential for cell surface integrity of C. glabrata.
RBR1, a Novel pH-Regulated Cell Wall Gene of Candida albicans, Is Repressed by RIM101 and Activated by NRG1
TLDR
It is shown that Rim101p contributes to the activation of known hypha-specific genes such as HWP1 and RBT1 but is also required for repression of the previously uncharacterized potential cell wall genes RBR1, RBR2, and RBR3.
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