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Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
In diabetic foot ulcers there is an excess of M MPs and a decrease of the tissue inhibitors of MMPs (TIMPs), which is probably one cause of impaired healing. Expand
Circulating Matrix Metalloproteinases 1, 2, 9 and Their Inhibitors TIMP-1 and TIMP-2 as Serum Markers of Liver Fibrosis in Patients With Chronic Hepatitis C: Comparison With PIIINP and Hyaluronic Acid
The results suggest that combining two serum markers reflecting fibrogenesis (PIIINP and fibrolysis (MMP-1) may provide a useful tool for evaluating liver fibrosis. Expand
The superoxide-generating oxidase of phagocytic cells
The present review is focused on recent data concerning the signaling pathway which leads to oxidase activation, including specific receptors, the production of second messengers, the organization of the oxidase complex and the molecular defects responsible for granulomatous disease. Expand
Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox
It is demonstrated that gp91phox is phosphorylated in human neutrophils by PKC to enhance its catalytic activity and assembly of the complex. Expand
NADPH oxidase homologs are required for normal cell differentiation and morphogenesis in Dictyostelium discoideum.
Cl cloning and characterisation of slime mould Dictyostelium discoideum homologs of the mammalian heme-containing subunit of flavocytochrome b, and the knockout of gene encoding NoxC, which contains two penta EF-hands, are consistent with a hypothesis connecting superoxide and calcium signalling during DictYostelia development. Expand
Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich
It is suggested that p67(PHOX) is phosphorylated by ERK2 and p38MAPK in vitro and in intact neutrophils on several selective sites but also that a C-terminal phosphorylation site may become accessible after a conformational change of the protein. Expand
Changing the Conformation State of Cytochrome b558 Initiates NADPH Oxidase Activation
The data suggest that the change of conformation in cytochrome b558, which initiates the electron transfer, can be mediated by effectors other than oxidase cytosolic factors p67phox and p47phox. Expand
Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases.
The most enhanced proteins in RA SF, the S100A8, S 100A9 and S00A12 proteins, distinguished RA from MIA with high accuracy and possible implication of resident cells in this increase may play a role in RA physiopathology. Expand
Sites of hormone action in the mammalian nephron.
  • F. Morel
  • Biology, Medicine
  • The American journal of physiology
  • 1 March 1981
It is concluded that biochemical approaches can be used as a means of investigating problems dealing with kidney physiology very near the cell level. Expand
Adenylate cyclase responsiveness to hormones in various portions of the human nephron.
The action sites for parathyroid hormone, salmon calcitonin, and arginine-vasopressin were investigated along the human nephron by measuring adenylate cyclase activity, using a single tubule in vitro microassay to suggest enzyme sensitivity to hormones as well preserved under the conditions used in this study. Expand