Circulating Matrix Metalloproteinases 1, 2, 9 and Their Inhibitors TIMP-1 and TIMP-2 as Serum Markers of Liver Fibrosis in Patients With Chronic Hepatitis C: Comparison With PIIINP and Hyaluronic Acid
The results suggest that combining two serum markers reflecting fibrogenesis (PIIINP and fibrolysis (MMP-1) may provide a useful tool for evaluating liver fibrosis.
The superoxide-generating oxidase of phagocytic cells
The present review is focused on recent data concerning the signaling pathway which leads to oxidase activation, including specific receptors, the production of second messengers, the organization of the oxidase complex and the molecular defects responsible for granulomatous disease.
Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox
- Houssam Raad, Marie-Helene Paciet, J. El-Benna
- Biology, Computer ScienceThe FASEB Journal
- 1 April 2009
It is demonstrated that gp91phox is phosphorylated in human neutrophils by PKC to enhance its catalytic activity and assembly of the complex.
NADPH oxidase homologs are required for normal cell differentiation and morphogenesis in Dictyostelium discoideum.
Sites of hormone action in the mammalian nephron.
- F. Morel
- Biology, MedicineAmerican Journal of Physiology
- 1 March 1981
It is concluded that biochemical approaches can be used as a means of investigating problems dealing with kidney physiology very near the cell level.
Human B Lymphocytes Synthesize the 92-kDa Gelatinase, Matrix Metalloproteinase-9*
- C. Trocmé, P. Gaudin, S. Berthier, C. Barro, P. Zaoui, F. Morel
- BiologyJournal of Biological Chemistry
- 7 August 1998
This study indicates that Epstein-Barr virus-immortalized B lymphocytes express 92-kDa gelatinase, the production of which can be modified by a variety of physiological and pharmacological signals which have been shown to differ according to the cell type.
Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich…
It is suggested that p67(PHOX) is phosphorylated by ERK2 and p38MAPK in vitro and in intact neutrophils on several selective sites but also that a C-terminal phosphorylation site may become accessible after a conformational change of the protein.
Changing the Conformation State of Cytochrome b558 Initiates NADPH Oxidase Activation
The data suggest that the change of conformation in cytochrome b558, which initiates the electron transfer, can be mediated by effectors other than oxidase cytosolic factors p67phox and p47phox.
Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases.
The most enhanced proteins in RA SF, the S100A8, S 100A9 and S00A12 proteins, distinguished RA from MIA with high accuracy and possible implication of resident cells in this increase may play a role in RA physiopathology.
Na-K-ATPase activity along the rabbit, rat, and mouse nephron.
The Na-K-ATPase activity measured in certain segments of the rat and rabbit nephrons in this study seems sufficient to account in theory for the active component of the net sodium transport found in the corresponding region of the nephron with either in vivo or in vitro single tubule microperfusion techniques.