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Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
The results suggest that DHEA S and PREG S control the NMDA response via sigma 1 receptors and that progesterone may act as a sigma antagonist. Expand
The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects.
The data demonstrating that the sigma1 receptor binds neurosteroids in physiological conditions will be reviewed and the physiological relevance of this interaction will be analyzed and the impact on physiopathological outcomes in memory and drug addiction will be illustrated. Expand
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors
Abstract The effects of two high-affinity σ ligands, DTG (1,3-di(2-tolyl)guanidine) and haloperidol, on the activation of dorsal hippocampus pyramidal neurons induced by microiontophereticExpand
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
It is shown that activation of the sigma1 receptor results in its translocation from the cytosol to the vicinity of the cell membrane and induces a robust and rapid decrease in hypoglossal activity, which is mediated by phospholipase C. Expand
A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway.
In frog melanotrope cells, a cholera toxin-sensitive, G protein-dependent inhibition of IA through a sigma 1 receptor activation, at least partially, underlies the excitatory effect of sigma ligands. Expand
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.
It is suggested that sigma receptors modulate the NMDA-induced neuronal activation in dorsal hippocampus pyramidal neurons induced by microiontophoretic application of N-methyl-D-aspartate. Expand
Pregnenolone sulfate enhances long‐term potentiation in CA1 in rat hippocampus slices through the modulation of N‐methyl‐D‐aspartate receptors
The ability of PREGS to enhance LTP in CA1 by accentuating the activity of NMDA receptors is shown, which might mediate the steroid‐induced enhancement of memory. Expand
Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons.
The results provide further support for a general mechanism for the intracellular sigma1 receptor to regulate Ca2+-dependent signal transduction and protein phosphorylation. Expand
In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.
The present data suggest that an important function of sigma receptors could be to modulate the NMDA response in this brain region. Expand
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis.
After PH in rodents, acute cholestasis and portal hypertension, via the nervous and endocrine routes, stimulate the secretion of AVP that may protect the liver against shear stress and bile acids overload. Expand