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Psychiatric aspects of impulsivity.
TLDR
Before treatment studies on impulsivity can move forward, measures of impulsivity that capture the core aspects of this behavior need to be refined and tested on the basis of an ideologically neutral model of impulsiveness.
Impulsivity: a link between bipolar disorder and substance abuse.
TLDR
Trait impulsivity is increased additively in bipolar disorder and substance abuse, and is increased in interepisode bipolar disorder only if a history of substance abuse is present.
Agonist-Like or Antagonist-Like Treatment for Cocaine Dependence with Methadone for Heroin Dependence: Two Double-Blind Randomized Clinical Trials
TLDR
The results provide support for the agonist- like (d-amphetamine) model in cocaine dependence treatment but not for antagonist-like (risperidone) treatment, and coincide with previous reports of amphetamine or ris peridone administered singly in cocaine-dependent individuals.
Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder.
TLDR
It is suggested that a history of severe suicidal behavior in patients with bipolar disorder is associated with impulsivity, manifested as a tendency toward rapid, unplanned responses.
Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging
TLDR
The finding that reduced integrity of anterior corpus callosum white matter in cocaine users is related to impaired impulse control and reduced ability to discriminate between target and catch stimuli is consistent with prior theories regarding frontal cortical involvement in impaired inhibitory control in cocaine-dependent subjects.
New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity
TLDR
New developments in the investigation of the neurocognition of impulsivity and compulsivity in humans are reviewed in order to advance the understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.
Dextroamphetamine for Cocaine-Dependence Treatment: A Double-Blind Randomized Clinical Trial
TLDR
A properly implemented agonist treatment regimen should improve retention and reduce illicit drug use, and the results provide support for additional examination of the agonist model in psychostimulantdependence treatment.
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