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Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line.
It is suggested that human blood cells are sensitive to mycotoxin exposure, that NIV is more toxic than DON which is more Toxic than FB1, and that DNA damage and apoptosis rather than plasma membrane damage and necrosis may be responsible for the observed cytotoxicity. Expand
Ochratoxin A in human serum samples collected in southern Italy from healthy individuals and individuals suffering from different kidney disorders.
Ochratoxin A was determined in human serum samples, collected in the south of Italy in November 1992, using ion-pair liquid chromatography and fluorescence detection, and a significant difference was found between the mean concentrations of the healthy group and of the group of patients treated by dialysis. Expand
Cytotoxicity of fungal metabolites to lepidopteran (Spodoptera frugiperda) cell line (SF-9).
The comparison with other bioassays showed that the SF-9 insect cell line could represent a further tool to screen for the toxic effects of fungal metabolites especially for beauvericin, gliotoxin, and zearalenone. Expand
Zearalenone and Reproductive Function in Farm Animals
The metabolism, the mechanistic aspects, the clinical reproductive symptoms and the in vitro effects on functional parameters of oocytes and sperm cells induced by zearalenone and its derivatives in farm animals are described. Expand
Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters.
A partial antagonism of mycotoxin-related estrogenic proliferation was seen when tamoxifen was used, confirming a receptor-dependent estrogenic response and further studies are needed to understand in human tissues the mechanisms of action of ZEA and its derivatives that may be found as contaminants in the human diet. Expand
Comparative Assessment of Fumonisin in Grain-Based Foods by ELISA, GC-MS, and HPLC.
The results suggested that although the immunoassay could be used for screening of fumonisin in food samples, higher estimates were attained by ELISA than by the other two methods particularly in the more contaminated samples. Expand
Verbascoside, isoverbascoside, and their derivatives recovered from olive mill wastewater as possible food antioxidants.
Individual verbascoside was more active as a scavenger of reactive oxygen species and as a chemopreventive agent protecting low-density lipoproteins from oxidative damage than the LH-20 fraction. Expand
The influence of lycopene on the proliferation of human breast cell line (MCF-7).
It is suggested that lycopene is involved in the modulation of the gap junction intercellular communication in this cell line, as observed for other cancer cell lines. Expand
Influence of mycotoxin zearalenone and its derivatives (alpha and beta zearalenol) on apoptosis and proliferation of cultured granulosa cells from equine ovaries
The simultaneous presence of apoptosis and proliferation in GC cultures treated with zearalenones could indicate that these mycotoxins could be effective in inducing follicular atresia in the mare. Expand
Investigation of Fungal Contamination in Sheep and Goat Cheeses in Southern Italy
One hundred and twenty-two samples of cheeses made from goat and sheep milk and a mixture of the two types, produced in Southern Italy by industrial establishments or artisans, were analysed for theExpand