• Publications
  • Influence
A communal catalogue reveals Earth’s multiscale microbial diversity
Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, aExpand
  • 718
  • 26
  • PDF
Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores.
Ca(2+) is a ubiquitous intracellular messenger which encodes information by temporal and spatial patterns of concentration. In spermatozoa, several key functions, including acrosome reaction andExpand
  • 121
  • 11
Productive penetration of rotavirus in cultured cells induces coentry of the translation inhibitor alpha-sarcin.
Internalization of rotavirus in MA104 cells was found to induce coentry of alpha-sarcin, a toxin that inhibits translation in cell-free systems and to which cells are normally impermeable. Entry ofExpand
  • 36
  • 5
Requirement for Vacuolar H+-ATPase Activity and Ca2+ Gradient during Entry of Rotavirus into MA104 Cells
ABSTRACT The mechanism by which rotavirus and other nonenveloped viruses enter the cell is still not clear. We have proposed an endocytosis model where the critical step for virus uncoating andExpand
  • 49
  • 4
Rotavirus interaction with isolated membrane vesicles.
To gain information about the mechanism of epithelial cell infection by rotavirus, we studied the interaction of bovine rotavirus, RF strain, with isolated membrane vesicles from apical membrane ofExpand
  • 43
  • 3
Cell lines susceptible to infection are permeabilized by cleaved and solubilized outer layer proteins of rotavirus.
It has previously been shown that trypsinized triple-layered particles of rotavirus induce destabilization of liposomes and membrane vesicles in the absence of Ca2+, a condition which leads toExpand
  • 37
  • 3
Carnivory in pitcher plants of the genus Heliamphora (Sarraceniaceae)
summary Field studies of Heliamphora nutans Benth., H. heterodoxa Steyerm., H. minor Gleason, H. ionasii maguire and H. tatei Gleason in the Guayana Highlands of Venezuela, show that the last namedExpand
  • 35
  • 3
The concentration of Ca2+ that solubilizes outer capsid proteins from rotavirus particles is dependent on the strain.
It has been previously shown that rotavirus maturation and stability of the outer capsid are calcium-dependent processes. More recently, it has been hypothesized that penetration of the cell membraneExpand
  • 56
  • 2
Developmental microbial ecology of the crop of the folivorous hoatzin
The hoatzin (Opisthocomus hoazin) is a South American strict folivorous bird, with a crop microbial ecosystem that ferments dietary plants. Chicks progressively become independent from the adult-fedExpand
  • 50
  • 2
  • PDF
Characterization of a Membrane Calcium Pathway Induced by Rotavirus Infection in Cultured Cells
ABSTRACT Some viruses induce changes in membrane permeability during infection. We have shown previously that the porcine strain of rotavirus, OSU, induced an increase in the permeability to Na+, K+,Expand
  • 38
  • 2