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The Relationship Between Serum Concentration and Therapeutic Effect of Haloperidol in Patients with Acute Schizophrenia
TLDR
This article aims to provide a comprehensive review of the study design of studies in patients with acute schizophrenia before the study data are used for decision-making, and recommends serum concentration assay of haloperidol for investigations of nonresponse to exclude patients with pseudo-drug resistance.
Lamotrigine Concentrations in Human Serum, Brain Tissue, and Tumor Tissue
TLDR
It was the aim to determine the LTG content in the brain and the tumor tissue and to bring the same into relation to the serum concentration and protein binding in neurosurgically operated patients.
Therapeutic drug monitoring of clozapine and relapse--a retrospective study of routine clinical data.
TLDR
It is tentatively concluded that serum levels of clozapine < 50 ng/ml are related to relapse irrespective of concurrent psychotropic drugs.
Population pharmacokinetics of 2% topical dorzolamide in the aqueous humor of humans.
TLDR
Pharmacokinetics of dorzolamide in the aqueous humor of humans are in comparable dimensions as previously reported in experimental trials in pigmented rabbits.
Influence of milk on the bioavailability of doxycycline — new aspects
TLDR
It is concluded that, like the other tetracyclines, doxycycline should not be administered together with milk.
Severe myalgia from an interaction between treatments with pantoprazole and methotrexate
TLDR
A 59 year old man with a folliculotropic cutaneous T cell lymphoma had been receiving treatment with interferon alfa-2a but after the treatment was discontinued because his tumour had relapsed, he started taking low dose pulse methotrexate, which led to partial immobility.
Therapeutic window of serum haloperidol concentration in acute schizophrenia and schizoaffective disorder.
TLDR
In an open clinical trial haloperidol serum levels were measured in 57 acute schizophrenia patients for at least three weeks and correlated with clinical outcome (percent change of Brief Psychiatric Rating Scale, BPRS) and a bisigmoidal model was used for data analysis.
The effect of anxiety and personality on the pharmacokinetics of oral midazolam.
TLDR
It is concluded that personality traits and anxiety levels had no effect on the pharmacokinetic variables of midazolam, and it is not necessary to obtain anxiety or personality scores to find the proper midAZolam dose for the individual patient.
Reduced haloperidol does not interfere with the antipsychotic activity of haloperidol in the treatment of acute schizophrenia.
TLDR
Serum concentrations of reduced haloperidol are of minor value for the interpretation of data of therapeutic drug monitoring of haloperdol in patients with acute schizophrenia and does not act as a 'false neuroleptic'.
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