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Estimation of Finescale Rainfall Fields Using Broadcast TV Satellite Links and a 4DVAR Assimilation Method
AbstractThis study proposes a method based on the use of a set of commercial satellite-to-Earth microwave links to rebuild finescale rainfall fields. Such microwave links exist all over the world andExpand
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Bone marrow mesenchymal stromal cells of patients with myeloproliferative disorders do not carry the JAK2-V617F mutation.
Myeloproliferative disorders (MPDs) are often associated with the presence of the JAK2-V617F mutation in hematopoietic cells. It is currently not known if this mutation is carried as well by boneExpand
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Exposure–response analysis of alectinib in crizotinib-resistant ALK-positive non-small cell lung cancer
PurposeAlectinib is a selective and potent anaplastic lymphoma kinase (ALK) inhibitor that is active in the central nervous system (CNS). Alectinib demonstrated robust efficacy in a pooled analysisExpand
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Population Pharmacokinetics of Fingolimod Phosphate in Healthy Participants
Fingolimod (FTY720) is a sphingosine 1‐phosphate receptor (S1PR) modulator currently being evaluated for the treatment of multiple sclerosis. Fingolimod undergoes phosphorylation in vivo to yieldExpand
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Modeling and simulations relating overall survival to tumor growth inhibition in renal cell carcinoma patients
PurposeTo assess the link between tumor growth inhibition (TGI) and overall survival (OS) based on historical renal cell carcinoma (RCC) data. To illustrate how simulations can help to identify TGIExpand
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Tumor Size and Overall Survival in Patients With Platinum-Resistant Ovarian Cancer Treated With Chemotherapy and Bevacizumab
Introduction: Ovarian cancer is now recognized as a constellation of distinct subtypes of neoplasia involving the ovary and related structures. As a consequence of this heterogeneity, the analysis ofExpand
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Using historical control information for the design and analysis of clinical trials with overdispersed count data.
Results from clinical trials are never interpreted in isolation. Previous studies in a similar setting provide valuable information for designing a new trial. For the analysis, however, the use ofExpand
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Model‐Based Drug Development in Oncology: What's Next?
Model‐based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in early (phase II) clinical studies. They can be used as end points and biomarkers to predictExpand
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Immunophenotypic patterns of CD8+ T cell subsets expressing CD8αα and IL-7Rα in viremic, aviremic and slow progressor HIV-1-infected subjects
Abstract Evidence from animal models suggests that the expression of CD8αα homodimer on CD8 + T cells plays a key role in the generation of long-lived memory cells. Here, we studied the quantitativeExpand
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Estimating time to disease progression comparing transition models and survival methods--an analysis of multiple sclerosis data.
This article reports an analysis that aims to quantify the effect of fingolimod, an oral treatment for relapsing remitting multiple sclerosis (MS), on disability progression. The standard approachExpand
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