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Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
The bone marrow at the crossroads of blood and immunity
The organization of regulatory elements in the bone marrow is reviewed and how these elements provide a dynamic means for the host to modulate stem cell and adaptive immune cell responses to physiological challenges are discussed.
Engineering pulmonary vasculature in decellularized rat and human lungs
The regeneration of functional pulmonary vasculature is reported by repopulating the vascular compartment of decellularized rat and human lung scaffolds with human cells, including endothelial and perivascular cells derived from induced pluripotent stem cells.
In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.
- Delphine Duguay, F. Mercier, +6 authors J. Hiscott
- Biology, MedicineCancer research
- 15 September 2002
In vivo effects on tumor growth correlated with higher mRNA expression of chemokines such as MIP-1beta, RANTES, and IP-10, as well as dramatic increases in vitro in the inducibility of cytokine mRNA such as IFN-beta, TNF-alpha and interleukin 6.
Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.
Bone marrow mesenchymal stromal cells of patients with myeloproliferative disorders do not carry the JAK2-V617F mutation.