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Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3
The genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development, which is a major cause underlying congenital malformations that result in digit polydactyly.
Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor Shox2 in Sinoatrial and Pacemaking Development
- R. Blaschke, Nathan D. Hahurij, A. G. Gittenberger-de Groot
- Biology, MedicineCirculation
- 10 April 2007
A critical function of Shox2 is postulated in the recruitment of sinus venosus myocardium comprising the sinoatrial nodal region and the venous valves, which is crucial for a comprehensive mechanistic understanding of arrhythmia-related diseases.
Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.
A significant increase in apoptosis localised in the outgrowing frontonasal process in embryonic day 10.0 of Alx3/Alx4 double mutant embryos is proposed to be the underlying cause of the subsequent malformations.
Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes
Studying the impact of Tbx15, Gli3, Alx4 and related genes on formation of the skeletal elements of the mouse shoulder and pelvic girdles revealed aspects of their genetic relationship, as well as functions that had been previously masked due to functional redundancy.
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs.
The results suggest a role for Prx genes in mediating epitheliomesenchymal interactions in inner ear and lower jaw and involve Prx1 and Prx2 in interactions between perichondrium and chondrocytes that regulate their proliferation or differentiation in the bones of the zeugopods.
Vertebrate aristaless-related genes.
- F. Meijlink, A. Beverdam, A. Brouwer, T. Oosterveen, D. T. Berge
- BiologyThe International journal of developmental…
Aristaless-related genes, a subset of the Paired-related homeobox genes, have in the past few years emerged as a group of regulators of essential events during vertebrate embryogenesis, and have been shown to have many different roles, including functions in the pituitary, left-right determination and limb development.
Retinoids regulate the anterior expression boundaries of 5′ Hoxb genes in posterior hindbrain
- T. Oosterveen, K. Niederreither, P. Dollé, P. Chambon, F. Meijlink, J. Deschamps
- BiologyThe EMBO journal
- 15 January 2003
We describe the regulatory interactions that cause anterior extension of the mouse 5′ Hoxb expression domains from spinal cord levels to their definitive boundaries in the posterior hindbrain between…
Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice.
The results document the involvement of distinct regulatory elements in Hox gene expression in subsets of cells with distinct developmental fate, situated at similar positions along the anteroposterior axis of the embryo.
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis.
In a panel of lymphoid cell lines, TCF-1 was exclusively expressed in the T cell lineage, and LEF-2 was detected at equivalent levels in pro- and pre-B cells and in all T lineage cells.