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Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process
Neutralization-reionization mass spectrometry (MS)1 is of unique value for preparing and characterizing highly reactive and unstable neutral species, such as the intermediate in the… Expand
Interpretation of Mass Spectra
- F. McLafferty
1. Introduction 2. Elemental Composition 3. The Molecular Ion 4. Basic Mechanisms of Ion Fragmentation 5. Postulation of Molecular Structures 6. Auxiliary Techniques 7. Theory of Unimolecular Ion… Expand
The Wiley/NBS registry of mass spectral data
The present 7-volume work, Registry of Mass Spectral Data, 2nd Edition is, by far, the most complete and up-to-date collection of mass spectra available in book form. Expand
Electron capture dissociation for structural characterization of multiply charged protein cations.
For proteins of < 20 kDa, this new radical site dissociation method cleaves different and many more backbone bonds than the conventional MS/MS methods that add energy directly to the even-electron ions. Expand
Infrared multiphoton dissociation of large multiply charged ions for biomolecule sequencing.
- D. Little, J. Speir, M. Senko, P. B. O’Connor, F. McLafferty
- Chemistry, Medicine
- Analytical chemistry
- 15 September 1994
Infrared multiphoton dissociation (IRMPD) of ionized proteins as large as carbonic anhydrase yields fragment information similar to, but with valuable additions to, that of other dissociation techniques. Expand
Electron Capture Dissociation of Gaseous Multiply-Charged Proteins Is Favored at Disulfide Bonds and Other Sites of High Hydrogen Atom Affinity
Disulfide bonds in gaseous multiply-protonated proteins are preferentially cleaved in the mass spectrometer by low-energy electrons, in sharp contrast to excitation of the ions by photons or… Expand
Thiamin biosynthesis in prokaryotes
The X-ray structures of thiamin phosphate synthase and 5-hydroxyethyl-4-methylthiazole kinase have been completed and the genes coding for the thienin transport system (thiBPQ) have been identified. Expand
Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway.
- K. Burns, Yun Xiang, C. Kinsland, F. McLafferty, T. Begley
- Chemistry, Medicine
- Journal of the American Chemical Society
- 1 March 2005
The substrates for Bacillus subtilis PLP synthase (YaaD and YaaE) are identified, and the first reconstitution of PLP biosynthesis using this pathway is described. Three partial reactions catalyzed… Expand
Top down versus bottom up protein characterization by tandem high- resolution mass spectrometry
- N. Kelleher, Hong-Yu Lin, G. Valaskovic, D. Aaserud, and Einar K. Fridriksson, F. McLafferty
- 16 January 1999
Characterization of larger proteins by mass spectrometry (MS) is especially promising because the information complements that of classical techniques and can be obtained on as little as 10-17 mol of… Expand