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RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire ofExpand
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CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.
In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendriticExpand
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The generation of thymus‐independent germinal centers depends on CD40 but not on CD154, the T cell‐derived CD40‐ligand
In this report, we show that the formation of germinal center (GC)‐like structures to thymus‐independent type 2 antigens in mice depends on intact signals through CD40, but does not depend on TExpand
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Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells
Innate lymphoid cells keep gut T cells in check Trillions of bacteria inhabit our guts. So do many types of immune cells, including T cells, which might be expected to attack these bacteria. How,Expand
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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium
Summary The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cellsExpand
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Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.
Lymphocytes from lymphotoxin (LT) alpha-deficient mice, which lack segregation of their B- and T-cell areas, acquire normal organization following adoptive transfer into RAG-deficient recipients,Expand
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The role of lymphoid tissue inducer cells in splenic white pulp development
CD4+CD3– lymphoid tissue inducer (LTi) cells are crucial for the development and organisation of lymph nodes and gut associated lymphoid tissues. In this report, we characterise their appearance inExpand
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The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.
Cross-linking class II molecules on resting human B cells can initiate phosphatidyl inositol turnover and an increase in intracellular calcium concentration levels comparable with that seen with theExpand
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Interventions based on the Theory of Mind cognitive model for autism spectrum disorder (ASD).
BACKGROUND The 'Theory of Mind' (ToM) model suggests that people with autism spectrum disorder (ASD) have a profound difficulty understanding the minds of other people - their emotions, feelings,Expand
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De facto, displaced, tacit: The sovereign articulations of the Tibetan Government-in-Exile
Abstract Based on ethnographic research on exiled Tibetan political institutions and practices in India, this paper investigates sovereignty in exile. The Tibetan Government-in-Exile (TGiE) remainsExpand
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