F. Maxfield

Publications321
h-index93
Citations29,952
Highly Influential Citations1,033
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Endocytic recycling
TLDR
After endocytosis, most membrane proteins and lipids return to the cell surface, but some membrane components are delivered to late endosomes or the Golgi, where they are sorted and recycled. Expand
Role of cholesterol and lipid organization in disease
TLDR
Significant recent progress has enhanced the understanding of the molecular and cellular basis of lipid-associated disorders such as Tangier disease, Niemann–Pick disease type C and atherosclerosis. Expand
Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells
TLDR
It is shown that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. Expand
Membrane transport in the endocytic pathway.
Despite controversies and debates, some fundamental properties of endosomes become apparent when comparing results from in vivo and in vitro strategies used to study endosomal membrane traffic. In… Expand
Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways
TLDR
These studies demonstrate the existence of two independent pathways for endosomal transport of proteins to the TGN from the plasma membrane, which are blocked by nocodazole, and the two pathways are also differentially affected by wortmannin. Expand
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking.
TLDR
Analysis of the cell surface distribution of the GPI-anchored folate receptor by electron microscopy confirms that multimerization regulates their sequestration in caveolae, but in the absence of agents that promote clustering they are diffusely distributed over the plasma membrane. Expand
Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor
TLDR
Results show that microglia express SRs that may play a significant role in the clearance of A beta plaques, and binding to SRs could activate inflammation responses that contribute to the pathology of Alzheimer's disease. Expand
An Endocytosed TGN38 Chimeric Protein Is Delivered to the TGN after Trafficking through the Endocytic Recycling Compartment in CHO Cells
To examine TGN38 trafficking from the cell surface to the TGN, CHO cells were stably transfected with a chimeric transmembrane protein, TacTGN38. We used fluorescent and 125I-labeled anti-Tac IgG and… Expand
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
TLDR
Using quantitative fluorescence microscopy, the endocytic route and kinetics of traffic of the bulk carrier, membrane lipids, are determined and it is shown that N-[N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl]- sphingosylphosphorylcholine (C6-NBD-SM) in endocytosed as bulk membrane. Expand
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
TLDR
It is proposed that dansylcadaverine inhibits EGF internalization by preventing it from clustering in clathrin-coated pits. Expand
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