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International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods.
TLDR
The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration.
A clinical index to define risk of asthma in young children with recurrent wheezing.
TLDR
It is concluded that the subsequent development of asthma can be predicted with reasonable accuracy using simple, clinically based parameters.
A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.
TLDR
It is concluded that CD14/-159 plays a significant role in regulating serum sCD14 levels and total serum IgE levels.
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.
TLDR
Children who started wheezing in early life and continued to wheeze at the age of six were more likely than the children who never wheezed to have mothers with a history of asthma, but do not have increased risks of asthma or allergies later in life.
Association of asthma with serum IgE levels and skin-test reactivity to allergens.
TLDR
It is concluded that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens the authors used to assess atopic status.
Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC)
TLDR
Prevalence surveys were conducted among representative samples of school children from locations in Europe, Asia, Africa, Australasia, North and South America to study the prevalence of asthma and allergies in Childhood.
Prevalence of asthma and atopy in two areas of West and East Germany.
TLDR
It is concluded that sensitization to aeroallergens is strikingly more frequent in West Germany than in East Germany and this may explain the differences in the prevalence of asthma and hay fever between the two parts of the country.
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children.
TLDR
Data suggest that the Arg130Gln polymorphism in IL-13, or others in close linkage with it, is associated with the development of the elevated serum IgE phenotype.
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