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Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry
STIM1 phosphorylation at ERK1/2 target sites can modulate SOCE by altering STIM1 binding to SOCs, because a significant decrease in FRET efficiency was observed between alanine substitution mutants of STIM 1–GFP and ORAI1–CFP.
Contribution of culture media to oxidative stress and its effect on human oocytes.
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
- Teresa Tiago, S. Simão, M. Aureliano, F. Martin-Romero, C. Gutiérrez-Merino
- Biology, ChemistryBiochemistry
- 21 March 2006
SIN-1, at concentrations that generate micromolar peroxynitrite fluxes, impaired the ability of ADP, and it was suggested that the inhibition of F-actin-stimulated S1 Mg(2+)-ATPase activity is produced by the oxidation of highly reactive cysteines of S1, located close to the catalytic center.
Fluorescence Measurements of Steady State Peroxynitrite Production Upon SIN-1 Decomposition: NADH Versus Dihydrodichlorofluorescein and Dihydrorhodamine 123
- F. Martin-Romero, Yolanda Gutiérrez-Martín, F. Henao, C. Gutiérrez-Merino
- BiologyJournal of Fluorescence
NADH was found to be less sensitive than dihydrorhodamine 123 and 2′,7′-dichlorodihydrofluorescein diacetate to oxidation by H2O2, which is produced during SIN-1 decomposition in common buffers.
Calcium signaling in mouse oocyte maturation: the roles of STIM1, ORAI1 and SOCE.
- C. Gómez-Fernández, Aida M. Lopez-Guerrero, E. Pozo-Guisado, I. Álvarez, F. Martin-Romero
- BiologyMolecular human reproduction
- 1 April 2012
There is an up-regulation of the expression of STIM1 at the germinal vesicle breakdown stage, and this expression remains steady during following maturation stages, suggesting that SOCE is involved in the maintenance of cytosolic Ca(2+)-spiking in the fertilized oocyte.
SELENOPROTEINS, SELENOPROTEIN mRNA EXPRESSION, FERTILITY, AND MORTALITY*
Evidence is provided that dietary selenium deficiency shortens, while supplementation of the diet withSelenium normalizes the Drosophila life span by a process that may involve the newly identified selenoproteins.
Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis.
Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1
- E. Pozo-Guisado, Vanessa Casas-Rua, Patricia Tomas-Martin, Aida M. Lopez-Guerrero, A. Álvarez-Barrientos, F. Martin-Romero
- BiologyJournal of Cell Science
- 15 July 2013
Using phosphospecific antibodies, it is demonstrated that ERK1/2 mediates STIM1 phosphorylation at Ser575, Ser608 and Ser621 during Ca2+ store depletion, and that Ca2- entry and store refilling restore phosphorylated levels to basal levels.
Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains
- Aida M. Lopez-Guerrero, Patricia Tomas-Martin, F. Martin-Romero
- BiologyScientific Reports
- 24 March 2017
This work contributes to understanding the role of STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho/ORAI/CTTN co-localize with cortactin (CTTN), a regulator of the cytoskeleton at membrane ruffle areas.
Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels.
- M. Garcia-Bereguiain, A. Samhan-Arias, F. Martin-Romero, C. Gutiérrez-Merino
- BiologyAntioxidants & redox signaling
It is concluded that H(2)S is a major modulator of calcium homeostasis in neurons as it induces activation of Ca(2+) entry through L-type Ca( 2+) channels, and thereby of neuronal activity.