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Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease
TLDR
The study suggests that host genetic variation in these regulators of complement activation plays a role in determining the occurrence of invasive disease versus asymptomatic colonization by this pathogen. Expand
Rotavirus vaccination in Europe: drivers and barriers.
TLDR
An overview of the status of rotavirus vaccination in Europe is presented and the drivers and barriers are discussed, including low awareness of disease burden, perception of unfavourable cost-effectiveness, and potential safety concerns. Expand
Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics.
TLDR
The limitations of RSV LRTI management, the drugs in development, and the remaining challenges related to study design, regulatory approval, and implementation are outlined. Expand
Heliox therapy in infants with acute bronchiolitis.
TLDR
In infants with moderate-to-severe respiratory syncytial virus bronchiolitis, heliox therapy enhanced their clinical respiratory status, according to the marked improvement in their clinical scores and the reduction of the accompanying tachycardia and tachypnea. Expand
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2
TLDR
ThehSBA response was robust as shown by the high proportion of responders at hSBA titres up to 16, which was similar for the two largest doses and ranged from 75·6 to 100·0% for the 120 μg dose and 67·9 to 99·9 for the 200 μg dose. Expand
Respiratory Syncytial Virus Seasonality: A Global Overview
TLDR
This is the first study to use original-source, high-quality surveillance data to establish a global, robust, and homogeneous report on global country-specific RSV seasonality. Expand
Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children.
TLDR
This study provides preliminary data regarding test accuracy of a 2-transcript host RNA signature discriminating bacterial from viral infection in febrile children. Expand
Implementing Universal Varicella Vaccination in Europe: The Path Forward
TLDR
Ways to overcome the barriers to move varicella forward as a truly vaccine preventable disease are discussed. Expand
Nasal continuous positive airway pressure with heliox in infants with acute bronchiolitis.
TLDR
In conclusion, Hx-nCPAP improved the clinical score, decreased the tachypnea and enhanced the CO2 elimination of infants with refractory acute bronchiolitis within 1h of administration, in a safe and non-invasive manner. Expand
Nasal Continuous Positive Airway Pressure With Heliox Versus Air Oxygen in Infants With Acute Bronchiolitis: A Crossover Study
TLDR
Nasal continuous positive airway pressure improves the clinical score and the CO2 elimination of infants with refractory bronchiolitis and is significantly enhanced when nasal continuous positiveAirway pressure is combined with heliox instead of air oxygen. Expand
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