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Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop.
It is shown that in human Tregs endogenous catecholamines subserve an autocrine/paracrine loop involving dopaminergic pathways and resulting in down-regulation of Treg function, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma. Expand
Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjects.
A systematic review of the literature showed that neutrophils were independent predictors of cardiovascular outcomes when analysed concomitantly with other markers of inflammation (WBC, CRP), highlighting the potential application of this inexpensive and readily available inflammatory marker for risk stratification in patients with ACS and/or cardiac revascularisation. Expand
Adrenergic modulation of immune cells: an update
The present review addresses emerging issues in the adrenergic modulation of immune cells, including the specific pattern of adrenoceptor expression on immune cells and their role and changes upon cell differentiation and activation. Expand
HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines.
In cultured PBMCs, intracellular CTs were reduced by both the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine and the chromaffin granule depletant reserpine, supporting the presence of active synthetic pathways in these cells. Expand
Dopaminergic Modulation of CD4+CD25high Regulatory T Lymphocytes in Multiple Sclerosis Patients during Interferon-β Therapy
Dopaminergic inhibition of Treg in MS patients is suppressed during IFN-β treatment, thus the effect may have a therapeutic repercussion. Expand
Interferon-γ and interferon-β affect endogenous catecholamines in human peripheral blood mononuclear cells: Implications for multiple sclerosis
IFNs are the first physiological compounds shown to affect endogenous CA in PBMCs: in view of the role of CA-dependent mechanisms in the immune response, these findings may help to better understand the mechanisms of action of IFN-beta as an immunomodulatory drug in MS. Expand
Foxp3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma.
A low but significant increase in the number of CD4+ T cells with phenotype and functional features of Treg cells in LC patients compared to normal healthy controls (NHC) was found, and the lack of correlation between cancer stage and the number or the function of peripheral T Reg cells inLC patients refuted the hypothesis that these cells are involved in tumor spreading. Expand
Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells.
The results indicate the existence of a CT lifecycle in human mononuclear cells and warrant further studies to investigate the role of adrenergic autoregulatory mechanisms in modulation of the immune response and in the pathogenesis of diseases involving the immune system. Expand
Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils.
The present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in neutrophil cells, and suggest the presence of storage and uptake mechanism. Expand
Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?
Multiple sclerosis (MS) is an autoimmune disorder of the CNS characterized by inflammation, demyelination and axonal loss. Classical evidence in experimental allergic encephalomyelitis, the animalExpand